Anti-BCMA antibody (ab5972)

Overview

• Product nameAnti-BCMA antibodySee all BCMA primary antibodies ...
• Description
  Rabbit polyclonal to BCMA
• Tested applicationsICC/IF, IHC-P, WB more details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  Synthetic peptide (Human).

• Positive controlHuman spleen tissue lysate, K562 or U937 whole cell lysates.
• General notesStable for one year.

  
  

  Members in the TNF superfamily regulate immune responses and induce apoptosis. Two novel members in the TNF family were recently identified and designated BAFF/BLyS/TALL1/THANK/zTNF4 and April/TALL2, respectively. BAFF was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. April regulates immunological and non immunological cell growth. Three receptors, BCMA (for B cell maturation protein), TACI, and BAFFR, for BAFF were recently identified. BCMA, like TACI, binds BAFF and April. BAFF and its receptors induce B cell development and survival, activate NF-kappaB and c-jun N-terminal kinase, and are involved in B cell associated autoimmune diseases.

Properties

• FormLiquid
• Storage instructionsStore at +4°C.
• Storage bufferPreservative: 0.02% Sodium Azide
  Constituents: PBS
• Concentration information loading...
• PurityImmunogen affinity purified
• Primary antibody notes Members in the TNF superfamily regulate immune responses and induce apoptosis. Two novel members in the TNF family were recently identified and designated BAFF/BLyS/TALL1/THANK/zTNF4 and April/TALL2, respectively. BAFF was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. April regulates immunological and non immunological cell growth. Three receptors, BCMA (for B cell maturation protein), TACI, and BAFFR, for BAFF were recently identified. BCMA, like TACI, binds BAFF and April. BAFF and its receptors induce B cell development and survival, activate NF-kappaB and c-jun N-terminal kinase, and are involved in B cell associated autoimmune diseases.
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Cancer
  • Growth factors
  • TNF

  • Signal Transduction
  • Growth Factors/Hormones
  • TNF

  • Immunology
  • Immune System Diseases
  • Antiviral Signaling

Applications

Target

• FunctionReceptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.
• Tissue specificityExpressed in mature B-cells, but not in T-cells or monocytes.
• Involvement in diseaseNote=A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2.
• Sequence similaritiesContains 1 TNFR-Cys repeat.
• Cellular localizationCell membrane. Endomembrane system. Perinuclear Golgi-like structures.

Target information above from: UniProt accession Q02223 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 608 Human
  • Omim: 109545 Human
  • SwissProt: Q02223 Human
  • Unigene: 2556 Human

• Alternative names
  B cell maturation antigen antibodyB Cell Maturation Factor antibodyB cell maturation protein antibody

  B-cell maturation protein antibodyBCM antibodyBCMA antibodyCD269 antibodyCD269 antigen antibodyTNFRSF17 antibodyTNR17_HUMAN antibodyTumor Necrosis Factor Receptor Member 17 antibodyTumor necrosis factor receptor superfamily member 17 antibody

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Anti-BCMA antibody images

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  Western blot - Anti-BCMA antibody (ab5972)
  
  
  Predicted band size : 20 kDa
  
  
  Western blot analysis of BCMA in human spleen (A) tissue lysate, K562 (B), and U937 (C) cell lysates with ab5972 at 5 µg/ml.
• 

  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - BCMA antibody (ab5972)

  ab5972 at 10µg/ml staining BCMA in human spleen cells by IHC

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  Immunocytochemistry/ Immunofluorescence-Anti-BCMA antibody(ab5972)
  Immunofluorescence of BCMA in Human Spleen cells using ab5972 at 10 ug/ml.