Overview

  • Product nameAnti-BCMA antibodySee all BCMA primary antibodies ...
  • Description
    Rabbit polyclonal to BCMA
  • Tested applicationsICC/IF, IHC-P, WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide (Human).

  • Positive control
    • Human spleen tissue lysate, K562 or U937 whole cell lysates.
  • General notesStable for one year.


    Members in the TNF superfamily regulate immune responses and induce apoptosis. Two novel members in the TNF family were recently identified and designated BAFF/BLyS/TALL1/THANK/zTNF4 and April/TALL2, respectively. BAFF was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. April regulates immunological and non immunological cell growth. Three receptors, BCMA (for B cell maturation protein), TACI, and BAFFR, for BAFF were recently identified. BCMA, like TACI, binds BAFF and April. BAFF and its receptors induce B cell development and survival, activate NF-kappaB and c-jun N-terminal kinase, and are involved in B cell associated autoimmune diseases.

Properties

  • FormLiquid
  • Storage instructionsStore at +4°C.
  • Storage bufferPreservative: 0.02% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • Primary antibody notes Members in the TNF superfamily regulate immune responses and induce apoptosis. Two novel members in the TNF family were recently identified and designated BAFF/BLyS/TALL1/THANK/zTNF4 and April/TALL2, respectively. BAFF was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. April regulates immunological and non immunological cell growth. Three receptors, BCMA (for B cell maturation protein), TACI, and BAFFR, for BAFF were recently identified. BCMA, like TACI, binds BAFF and April. BAFF and its receptors induce B cell development and survival, activate NF-kappaB and c-jun N-terminal kinase, and are involved in B cell associated autoimmune diseases.
  • Clonality Polyclonal
  • IsotypeIgG
  • Research Areas

Applications

Our Abpromise guarantee covers the use of ab5972 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use a concentration of 20 µg/ml.
IHC-P Use a concentration of 10 µg/ml.
WB Use a concentration of 2 - 5 µg/ml. Predicted molecular weight: 20 kDa.Can be blocked with BCMA peptide (ab6087).

Target

  • FunctionReceptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.
  • Tissue specificityExpressed in mature B-cells, but not in T-cells or monocytes.
  • Involvement in diseaseNote=A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2.
  • Sequence similaritiesContains 1 TNFR-Cys repeat.
  • Cellular localizationCell membrane. Endomembrane system. Perinuclear Golgi-like structures.
  • Information by UniProt
  • Database links
  • Alternative names
    • B cell maturation antigen antibody
    • B Cell Maturation Factor antibody
    • B cell maturation protein antibody
    • B-cell maturation protein antibody
    • BCM antibody
    • BCMA antibody
    • CD269 antibody
    • CD269 antigen antibody
    • TNFRSF17 antibody
    • TNR17_HUMAN antibody
    • Tumor Necrosis Factor Receptor Member 17 antibody
    • Tumor necrosis factor receptor superfamily member 17 antibody
    see all

Anti-BCMA antibody images



  • Predicted band size : 20 kDa


    Western blot analysis of BCMA in human spleen (A) tissue lysate, K562 (B), and U937 (C) cell lysates with ab5972 at 5 µg/ml.
  • ab5972 at 10µg/ml staining BCMA in human spleen cells by IHC

  • Immunofluorescence of BCMA in Human Spleen cells using ab5972 at 10 ug/ml.

References for Anti-BCMA antibody (ab5972)

This product has been referenced in:
  • Müller N  et al. B Lymphocyte Stimulator (BLyS) Is Expressed in Human Adipocytes In Vivo and Is Related to Obesity but Not to Insulin Resistance. PLoS One 9:e94282 (2014). WB ; Human . Read more (PubMed: 24728308) »
  • Brady G  et al. Downregulation of RUNX1 by RUNX3 requires the RUNX3 VWRPY sequence and is essential for Epstein-Barr virus-driven B-cell proliferation. J Virol 83:6909-16 (2009). Read more (PubMed: 19403666) »

See all 2 Publications for this product

Product Wall

The immunogen is from the C-terminal region of BCMA, so the antibody binds the intracellular domain.

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This product has not been tested in mouse samples but it is unlikely to react, as the immunogen has very low homology with mouse.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"