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Product Name
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BCRP/ABCG2 antibody [BXP-34] - Hematopoietic/Neural Stem Cell Marker
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See all BCRP/ABCG2 antibodies (7)...
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Product type
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Primary antibodies
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Description
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Mouse monoclonal [BXP-34] to BCRP/ABCG2 - Hematopoietic/Neural Stem Cell Marker
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Immunogen
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BCRP over-expressing cell line MCF 7 MR.
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Reacts with
(species key)
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Hu
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Specificity
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This antibody does not cross react with the human MDR1, MRP1, MRP2 or MRP5 gene products.
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Epitope
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Internal epitope.
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Tested applications
(see key)
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ICC, IHC-Fr
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Abreviews
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Application notes
(see key)
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Recommended dilutions
This antibody does not work in Western blot.
Optimal dilutions / concentrations should be determined by the end user.
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Cellular localization
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Plasma membrane, integral membrane protein
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Research areas
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Cancer >> Drug resistance >> MRP-related proteins
Signal Transduction >> Metabolism >> Drug metabolism
Stem Cells >> Hematopoietic Progenitors >> Surface Molecules
Stem Cells >> Neural Stem Cells >> Surface Molecules
Signal Transduction >> Metabolism >> Plasma Membrane >> ATPases
Tags & Cell Markers >> Cell Type Markers >> Tumor Associated
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Relevance
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An ABC transporter. Allows efflux of Hoechst dye, a property that has been used to separate bone marrow side population cells, which express BCRP/ABCG2. Appears to play a major role in the multidrug resistance phenotype of a specific MCF-7 breast cancer cell line. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase in the efflux of rhodamine 123.
Breast Cancer Resistance Protein (BCRP) is a 70 kDa ATP-Binding Cassette membrane transport protein involved in multidrug resistance. BCRP may be over-expressed in cancer cell lines selected with doxorubicin / verapamil, topotecan or mitoxantrone.
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Alternative names BCRP/ABCG2 antibody [BXP-34] - Hematopoietic/Neural Stem Cell Marker (ab3379) |
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Mouse
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Clonality
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Monoclonal
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Clone number
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BXP-34
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Isotype
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IgG
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Storage buffer
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PBS with 1% BSA and 0.1% sodium azide Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS
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Form
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Liquid
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Concentration
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0.250 mg/ml
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Storage instructions
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Store at +4°C.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this BCRP/ABCG2 antibody [BXP-34] - Hematopoietic/Neural Stem Cell Marker is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to BCRP/ABCG2
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