Loading...
You have changed your country from
to
. Please be aware that this will change the currency in the purchasing process.
Products:Tags & Cell Markers >> Cell Type Markers >> Tumor Associated
Overview
Product name
Anti-BCRP/ABCG2 antibody [BXP-34] - Hematopoietic/Neural Stem Cell Marker
See all BCRP/ABCG2 products (10) ...
Description
Mouse monoclonal [BXP-34] to BCRP/ABCG2 - Hematopoietic/Neural Stem Cell Marker
Specificity
This antibody does not cross react with the human MDR1, MRP1, MRP2 or MRP5 gene products.
Tested applications
ICC, IHC-Frmore details
Cross reactivity
Reacts with
Human
Immunogen
BCRP over-expressing cell line MCF 7 MR.
Epitope
Internal epitope.
Properties
Form
Liquid
Storage instructions
Store at +4°C.
Storage buffer
PBS with 1% BSA and 0.1% sodium azide
Concentration
Concentration information loading...
Purity
Concentrated Culture Supernatant
Primary antibody notes
Breast Cancer Resistance Protein (BCRP) is a 70 kDa ATP-Binding Cassette membrane transport protein involved in multidrug resistance. BCRP may be over-expressed in cancer cell lines selected with doxorubicin / verapamil, topotecan or mitoxantrone.
Clonality
Monoclonal
Clone number
BXP-34
Isotype
IgG
Research areas
Cancer >> Drug resistance >> MRP-related proteins
Signal Transduction >> Metabolism >> Drug metabolism
Stem Cells >> Hematopoietic Progenitors >> Surface Molecules
Stem Cells >> Neural Stem Cells >> Surface Molecules
Signal Transduction >> Metabolism >> Plasma Membrane >> ATPases
Tags & Cell Markers >> Cell Type Markers >> Tumor Associated
Applications
Show applications key
Our Abpromise guarantee covers the use of ab3379 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ICC
IHC-Fr
Application notes
This antibody does not work in Western blot.
Optimal dilutions / concentrations should be determined by the end user.
Target
Function
Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. May be involved in brain-to-blood efflux. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase in the efflux of rhodamine 123.
Tissue specificity
Highly expressed in placenta. Low expression in small intestine, liver and colon.
Sequence similarities
Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
Contains 1 ABC transmembrane type-2 domain.
Contains 1 ABC transporter domain.
Post-translational
modifications
Glycosylation-deficient ABCG2 is normally expressed and functional.
Cellular localization
Cell membrane.
Target information above from: UniProt accessionQ9UNQ0
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- ABC15 antibody
- ABCG 2 antibody
- ABCG2 antibody
see all
Database links
- Entrez Gene: 9429 Human
- Omim: 603756 Human
- SwissProt: Q9UNQ0 Human
- Unigene: 480218 Human
References for Anti-BCRP/ABCG2 antibody [BXP-34] - Hematopoietic/Neural Stem Cell Marker (ab3379)
ab3379 has not yet been referenced specifically in any publications.
Publishing research using ab3379? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"