Overview

  • Product nameAnti-BDNF antibodySee all BDNF primary antibodies ...
  • Description
    Sheep polyclonal to BDNF
  • SpecificityLess than 1% cross reactivity against mouse NGF, recombinant human NT3 or Neurotrophin 4.
  • Tested applicationsIHC-FoFr, WB, ICC/IF, Inhibition Assaymore details
  • Species reactivity
    Reacts with: Rat, Human
  • Immunogen

    Recombinant full length protein (Human)

  • General notesAntibacterial agents may be required for short term storage.

Properties

Applications

Our Abpromise guarantee covers the use of ab24491 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-FoFr Use at an assay dependent concentration. PubMed: 21667226
WB 1/200 - 1/2000. Predicted molecular weight: 28 kDa.
ICC/IF Use at an assay dependent dilution.
Inhibition Assay 1/10 - 1/50.

Target

  • FunctionDuring development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.
  • Tissue specificityBrain. Highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. Also expressed in heart, lung, skeletal muscle, testis, prostate and placenta.
  • Involvement in diseaseCongenital central hypoventilation syndrome
  • Sequence similaritiesBelongs to the NGF-beta family.
  • Post-translational
    modifications
    The propeptide is N-glycosylated and glycosulfated.
    Converted into mature BDNF by plasmin (PLG).
  • Cellular localizationSecreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • Abrineurin antibody
    • BDNF antibody
    • BDNF antibody
    • BDNF_HUMAN antibody
    • Brain Derived Neurotrophic Factor antibody
    • Brain-derived neurotrophic factor antibody
    • MGC34632 antibody
    • MGC34632 antibody
    • Neurotrophin antibody
    see all

References for Anti-BDNF antibody (ab24491)

This product has been referenced in:
  • Park JH  et al. Extract from Terminalia chebula seeds protect against experimental ischemic neuronal damage via maintaining SODs and BDNF levels. Neurochem Res 36:2043-50 (2011). IHC-FoFr, WB ; Gerbil . Read more (PubMed: 21667226) »

See 1 Publication for this product

Product Wall

I can confirm that the antibody ab24491 will recognise the mature form of BDNF as it is a polyclonal antibody which is raised against recombinant BDNF. I would predict the antibody to work as there is a 96% homology between the human protein and the m...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"