Anti-BDNF antibody (ab27932)

Overview

  • Product nameAnti-BDNF antibody
    See all BDNF primary antibodies
  • Description
    Chicken polyclonal to BDNF
  • SpecificityThis antibody does not cross react with other neurotrophic factors.
  • Tested applicationsELISA, WB, ICC, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant full length protein (Human).

Properties

Applications

Our Abpromise guarantee covers the use of ab27932 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use a concentration of 1 µg/ml.
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 28 kDa.
ICC Use a concentration of 1 - 10 µg/ml.
IHC-P Use at an assay dependent concentration.

Target

  • FunctionDuring development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.
  • Tissue specificityBrain. Highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. Also expressed in heart, lung, skeletal muscle, testis, prostate and placenta.
  • Involvement in diseaseCongenital central hypoventilation syndrome
  • Sequence similaritiesBelongs to the NGF-beta family.
  • Post-translational
    modifications
    The propeptide is N-glycosylated and glycosulfated.
    Converted into mature BDNF by plasmin (PLG).
  • Cellular localizationSecreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • Abrineurin antibody
    • ANON2 antibody
    • BDNF antibody
    • BDNF_HUMAN antibody
    • Brain Derived Neurotrophic Factor antibody
    • Brain-derived neurotrophic factor antibody
    • BULN2 antibody
    • MGC34632 antibody
    • Neurotrophin antibody
    see all

References for Anti-BDNF antibody (ab27932)

ab27932 has not yet been referenced specifically in any publications.

Product Wall

Merci de votre intérêt pour nos anticorps.

Voici une les anticorps anti BDNF déjà testés par nous en coupes congélées et sur le tissu du rat, pour lesquels nous avons soit un retour d'un utilisateur (Abreview) soit une référence.

...

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Thank you for contacting Abcam.

As you mentioned the level of homology between species is highly conserved and so we cannot guarantee that any of our BDNF antibodies would only recognize the human sequence. On our datasheets, if we only say f...

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Abreviews
Abcam has not validated the combination of species/application used in this Abreview.
Application Western blot
Sample Chicken Tissue lysate - whole (brain)
Loading amount 5.2 µg
Specification brain
Treatment 1ul 200* proteinase inhibitor
Gel Running Conditions Reduced Denaturing
Blocking step BSA as blocking agent for 4 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 4°C
Username

Ms. Ying Jiang

Verified customer

Submitted Sep 22 2011

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"