Anti-BDNF antibody (ab6200)
- Product nameAnti-BDNF antibodySee all BDNF primary antibodies ...
- DescriptionRabbit polyclonal to BDNF
- SpecificityBy dot blots, less than 0.1% cross-reactivity against mouse NGF, recombinant human NT3 or neurotrophin 4/5. Cross reactivity: Known to react with BDNF from rat and human. Cross-reactivity with other species has not been determined yet.
- Tested applicationsDot Blot, IHC-Fr, Neutralising, WB more details
- Species reactivityReacts with: Human
Recombinant full length protein (Human).
- General notesThis antibody has proven particularly useful for western blot, immunohistochemistry and biological inhibition. For immunohistochemistry, cell bodies are clearly stained as well as some nerve terminals in the dorsal horn of the rat spinal cord. The antiserum does not stain the finest nerve terminals.
- Storage instructionsStore at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C (add glycerol to a final volume of 50% for extra stability). Avoid repeated freeze / thaw cycles.
- PurityWhole antiserum
- Clonality Polyclonal
Our Abpromise guarantee covers the use of ab6200 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Western Blot: 1/1,000
1 site ELISA: 1/1,000
Biological Inhibition: 5- 10 ul/ gm body weight in vivo.
- FunctionDuring development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.
- Tissue specificityBrain. Highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. Also expressed in heart, lung, skeletal muscle, testis, prostate and placenta.
- Involvement in diseaseCongenital central hypoventilation syndrome (CCHS) [MIM:209880]: Rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Sequence similaritiesBelongs to the NGF-beta family.
modificationsThe propeptide is N-glycosylated and glycosulfated.
Converted into mature BDNF by plasmin (PLG).
- Cellular localizationSecreted.
- Abrineurin antibodyBDNF antibodyBDNF antibody
- BDNF_HUMAN antibodyBrain Derived Neurotrophic Factor antibodyBrain-derived neurotrophic factor antibodyMGC34632 antibodyMGC34632 antibodyNeurotrophin antibody
References for Anti-BDNF antibody (ab6200)
ab6200 has not yet been referenced specifically in any publications.