Anti-BDNF antibody (ab72439)

Overview

• Product nameAnti-BDNF antibodySee all BDNF primary antibodies ...
• Description
  Rabbit polyclonal to BDNF
• SpecificityThis antibody appears to be specific for BDNF; it shows no cross-reactivity with other neurotrophic factors.
• Tested applicationsWB, IHC-P, IHC-Fr more details
• Species reactivity
  Reacts with: Mouse, Human
  
• Immunogen

  A synthetic peptide from human BDNF conjugated to an immunogenic carrier protein. The peptide is homologous in many other species including rat, mouse, zebra fish and xenopus. Peptide available as ab97400.

Properties

• FormLiquid
• Storage instructionsStore at +4°C short term (1-2 weeks). Add glycerol to a final volume of 50%, aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
• Storage bufferPreservative: None
  Constituents: 1X PBS
• Concentration information loading...
• PurityIgG fraction
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Metabolism
  • Types of disease
  • Diabetes

  • Metabolism
  • Types of disease
  • Obesity

  • Cardiovascular
  • Atherosclerosis
  • Thrombosis
  • Other

  • Cardiovascular
  • Atherosclerosis
  • Diabetes associated

  • Neuroscience
  • Neurology process
  • Neurodegenerative disease
  • Huntington's disease

  • Neuroscience
  • Neurology process
  • Growth and Development
  • Neurotrophins

  • Neuroscience
  • Neurology process
  • Neurodegenerative disease
  • Alzheimer's disease
  • Other

Applications

Target

• FunctionDuring development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.
• Tissue specificityBrain. Highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. Also expressed in heart, lung, skeletal muscle, testis, prostate and placenta.
• Involvement in diseaseCongenital central hypoventilation syndrome (CCHS) [MIM:209880]: Rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia. Note=The disease is caused by mutations affecting the gene represented in this entry.
• Sequence similaritiesBelongs to the NGF-beta family.
• Post-translational
  modificationsThe propeptide is N-glycosylated and glycosulfated.
  Converted into mature BDNF by plasmin (PLG).
• Cellular localizationSecreted.

Target information above from: UniProt accession P23560 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 627 Human
  • Entrez Gene: 12064 Mouse
  • Omim: 113505 Human
  • SwissProt: P23560 Human
  • SwissProt: P21237 Mouse
  • Unigene: 502182 Human
  • Unigene: 1442 Mouse

• Alternative names
  Abrineurin antibodyBDNF antibodyBDNF antibody

  BDNF_HUMAN antibodyBrain Derived Neurotrophic Factor antibodyBrain-derived neurotrophic factor antibodyMGC34632 antibodyNeurotrophin antibody

  see all

Anti-BDNF antibody images

• 

  Western blot - BDNF antibody (ab72439)
  Anti-BDNF antibody (ab72439) at 1/10 dilution + SK N SH (Human neuroblastoma) Whole Cell Lysate at 10 µg
  
  Secondary
  Goat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution
  
  Predicted band size : 28 kDa
  Observed band size : 28 kDa
  Additional bands at : 52 kDa. We are unsure as to the identity of these extra bands.