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Anti-BDNF antibody (ab9793)

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    Overview

    Product name

    Anti-BDNF antibody
    See all BDNF products (22) ...

    Description

    Rabbit polyclonal to BDNF

    Tested applications

    ELISA, WB, Functional Studiesmore details

    Cross reactivity

    Reacts with

    Human

    Immunogen

    Highly pure (>98%) recombinant BDNF (human Brain-Derived Neurotrophic Factor).

    Properties

    Form

    Lyophilised:
    Reconstitute with 200µl of sterile water.

    Storage instructions

    Store at +4°C.

    Storage buffer

    PBS, pH 7.4, no preservative, sterile filtered

    Concentration

    Concentration information loading...

    Purity

    Immunogen affinity purified

    Clonality

    Polyclonal

    Isotype

    unknown

    Light chain type

    unknown

    Applications

    Show applications key

    Our Abpromise guarantee covers the use of ab9793 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • ShowHide

      ELISA

       ELISA: Use at an assay d...Read more →

      ELISA: Use at an assay dependent dilution. (To detect hBDNF by indirect ELISA (using 100 µl/well antibody solution) a concentration of 0.5 - 2.0 µg/ml of this antibody is required. The detection limit is at least 0.2 - 0.4 ng/well of recombinant hBDNF. )

    • WB: Use a concentration of 0.1 - 0.2 µg/ml.(The detection limit for recombinant hBDNF is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions)

    • ShowHide

      Functional Studies

       FuncS: Use at an assay d...Read more →

      FuncS: Use at an assay dependent dilution. (To yield one-half maximal inhibition [ND50] of the biological activity of hBDNF (2.0 µg/ml), a concentration of 0.54-0.81 µg/ml of this antibody is required.)

    Target

    Function

    During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.

    Tissue specificity

    Brain. Highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. Also expressed in heart, lung, skeletal muscle, testis, prostate and placenta.

    Involvement in disease

    Defects in BDNF are a cause of congenital central hypoventilation syndrome (CCHS) [MIM:209880]; also known as congenital failure of autonomic control or Ondine curse. CCHS is a rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia. CCHS is frequently complicated with neurocristopathies such as Hirschsprung disease that occurs in about 16% of CCHS cases.

    Sequence similarities

    Belongs to the NGF-beta family.

    Post-translational
    modifications

    The propeptide is N-glycosylated and glycosulfated.
    Converted into mature BDNF by plasmin (PLG).

    Cellular localization

    Secreted.

    Target information above from: UniProt accessionP23560 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010).

    Information by UniProt

    Alternative names

    • Abrineurin antibody
    • BDNF antibody
    • BDNF antibody
    • BDNF_HUMAN antibody
    • Brain Derived Neurotrophic Factor antibody
    • Brain-derived neurotrophic factor antibody
    • MGC34632 antibody
    • MGC34632 antibody
    • Neurotrophin antibody
    see all

    References for Anti-BDNF antibody (ab9793)

    ab9793 has not yet been referenced specifically in any publications.

    Publishing research using ab9793? Please let us know so that we can cite the reference in this datasheet

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"