BIN1 antibody [2F11] (ab84974)

Product Name 

BIN1 antibody [2F11]

Product type 

Primary antibodies

Description 

Mouse monoclonal [2F11] to BIN1

Immunogen 

GST chimeric protein that encoded human Bin1 BAR domain.

Reacts with 
(species key)

Hu

Tested applications 
(see key)

IHC-Fr, IHC-P

Abreviews 

Customer reviews (see key)

Read about Abreviews

Application notes 
(see key)

Recommended dilutions
IHC-P: 1/40 for 60 mins at room temperature, using a Biotin based system. For optimal staining, the sections should be pretreated with an antigen unmasking solution.
IHC-Fr: 1/40 for 60 mins at room temperature, using a Biotin based system.


Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Positive control 
(see definition)

Human Prostate Cancer tissue.

Cellular localization 

Cytoplasmic (Isoform IIa) and Nuclear (isoform BIN1)

Research areas 

Cancer >> Oncoproteins/suppressors >> Tumor suppressors >> Other
Cancer >> Cell cycle >> Cell cycle inhibitors >> Other
Chromatin and Nuclear Signaling >> Cell cycle >> Cell Cycle Inhibitors >> Other
Chromatin and Nuclear Signaling >> Transcription >> Cancer susceptibility >> Tumor Suppressors
Microbiology >> Interspecies Interaction >> Host Virus Interaction
Cell Biology >> Cell Cycle >> Cell Cycle Inhibitors >> Other

Relevance 

The identification and analysis of tumor suppressors is of major importance for improved diagnosis and treatment of tumors. Bin1 (Box-dependent myc interacting protein 1, also known as SH3P9, amphiphysin II and amphl/amphiphysin-like) is a novel protein that has features of a tumor suppressor. Bin1 interacts with and inhibits the oncogenic activity of the myc oncoprotein that has a major role in many human cancers. The loss of Bin1 may contribute to growth deregulation in cancer cells in carcinoma of the breast, colon, lung, cervix, prostate and liver. Bin1 also interacts with HCV NS5A through its SH3 domain.

Database links 

Raised in 

Mouse

Clonality 

Monoclonal

Clone number 

2F11

Isotype 

IgG1

Purity 

Protein A purified

Storage buffer 

Preservative: 0.1% Sodium Azide
Constituents: PBS

Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS

Form 

Liquid

Storage instructions 

Store at +4°C.

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