Anti-BIN1 antibody (ab125444)
- Product nameAnti-BIN1 antibodySee all BIN1 primary antibodies ...
- DescriptionRabbit polyclonal to BIN1
- Tested applicationsWB more details
- Species reactivityReacts with: Mouse
Predicted to work with: Human
Synthetic peptide corresponding to a region within internal amino acids 341-390 (PVPPPPKHTP SKEMKQEQIL SLFDDAFVPE ISVTTPSQFE APGPFSEQAS) of Mouse BIN1 (NP_033798).
- Positive controlMouse pancreas lysate.
- Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
- Storage bufferConstituents: 97% PBS, 2% Sucrose
- Concentration information loading...
- PurityImmunogen affinity purified
- Clonality Polyclonal
Our Abpromise guarantee covers the use of ab125444 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||WB: Use a concentration of 1 µg/ml. Predicted molecular weight: 64 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.|
- FunctionMay be involved in regulation of synaptic vesicle endocytosis. May act as a tumor suppressor and inhibits malignant cell transformation.
- Tissue specificityUbiquitous. Highest expression in the brain and muscle. Isoform IIA is expressed only in the brain where it is concentrated in axon initial segments and nodes of Ranvier. Isoform BIN1 is widely expressed with highest expression in skeletal muscle.
- Involvement in diseaseDefects in BIN1 are the cause of centronuclear myopathy autosomal recessive (ARCNM) [MIM:255200]; also known as autosomal recessive myotubular myopathy. Centronuclear myopathies are congenital muscle disorders characterized by progressive muscular weakness and wasting involving mainly limb girdle, trunk, and neck muscles. It may also affect distal muscles. Weakness may be present during childhood or adolescence or may not become evident until the third decade of life. Ptosis is a frequent clinical feature. The most prominent histopathologic features include high frequency of centrally located nuclei in muscle fibers not secondary to regeneration, radial arrangement of sarcoplasmic strands around the central nuclei, and predominance and hypotrophy of type 1 fibers.
- Sequence similaritiesContains 1 BAR domain.
Contains 1 SH3 domain.
modificationsPhosphorylated by protein kinase C.
- Cellular localizationCytoplasm and Nucleus.
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Anti-BIN1 antibody images
Anti-BIN1 antibody (ab125444) at 1 µg/ml + Mouse pancreas lysate at 10 µg
Predicted band size : 64 kDa
References for Anti-BIN1 antibody (ab125444)
ab125444 has not yet been referenced specifically in any publications.