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Overview

  • Product nameBMP3 protein (Active)See all BMP3 proteins and peptides ...
  • Protein descriptionRecombinant human BMP-3 is a disulfide linked homodimeric protein that corresponds to residues 361 to 472 of the 472 amino acid BMP-3 precursor protein.
  • Uniprot accessionP12645
  • Molecular weight12.500kDa
  • Protein length110 amino acids
  • Expression hostHEK 293 cells

    • Properties

  • Purity> 95 % by SDS-PAGE
  • Purification notesPurity is greater than 95% by SDS-PAGE gel and HPLC analyses.
  • Biological activityDetermined by its ability to inhibit BMP-2-induced alkaline phosphatase production by ATDC-5 cells.
  • FormLyophilised:The lyophilized protein is stable at room temperature for up to 1 month. Working aliquots stored with a carrier protein are stable for at least 3 months at -20°C to -80°C.
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.This product is an active protein and may elicit a biological response in vivo, handle with caution.
  • Storage bufferPreservative: None
  • Concentration information loading...
  • SequenceMQWIEPRNCA RRYLKVDFAD IGWSEWIISP KSFDAYYCSG ACQFPMPKSL KPSNHATIQS IVRAVGVVPG IPEPCCVPEK MSSLSILFFD ENKNVVLKVY PNMTVESCAC R
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab97412 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    Functional Studies FuncS: Use at an assay dependent dilution.
    SDS-PAGE SDS-PAGE: Use at an assay dependent dilution.
    HPLC HPLC: Use at an assay dependent dilution.

    Protein info

    • Alternative names
        BMP-3BMP-3Abmp3
        BMP3_HUMANBMP3ABone morphogenetic protein 3Bone morphogenetic protein 3 (osteogenic)Bone morphogenetic protein 3AOsteogenin
      see all
  • FunctionNegatively regulates bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification.
  • Tissue specificityExpressed in adult and fetal cartilage.
  • Sequence similaritiesBelongs to the TGF-beta family.
  • Cellular localizationSecreted.

    • Target information above from: UniProt accession P12645 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    References for BMP3 protein (Active) (ab97412)

    ab97412 has not yet been referenced specifically in any publications.

    Publishing research using ab97412 ? Please let us know so that we can cite the reference in this datasheet

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