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Products:Signal Transduction >> Growth Factors/Hormones >> TGF
Overview
Product name
BMP7 protein
See all BMP7 products (7) ...
Protein description
Recombinant full length protein (Human), a monomeric, non-glycosylated, polypeptide chain containing 139 amino acids and having a molecular mass of 16kDa. The sequence of the first five N-terminal amino acids was determined and was found to be S-T-G-S-K.
Expression host
E. coli
Properties
Purity
>95% by SDS-PAGE
Purification notes
Purified by proprietary chromatographic techniques.
Form
Lyophilised:
Reconstitute the lyophilized BMP7 in sterile 20mM Acetic Acid, to not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Storage instructions
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
Constituents: 10mM Sodium citrate, pH 3.5
Concentration
Concentration information loading...
Additional notes
For long term storage after reconstitution, it is recommended to add a carrier protein (0.1% HSA or BSA).
Research areas
Developmental Biology >> Organogenesis >> Excretory system development >> Kidney development
Developmental Biology >> Organogenesis >> Nervous system development
Cancer >> Cell cycle >> Cell differentiation
Stem Cells >> Signaling Pathways >> TGF beta >> Secreted
Cell Biology >> Cell Cycle >> Cell differentiation
Signal Transduction >> Cytoskeleton / ECM >> Extracellular Matrix >> Structures >> Bone
Signal Transduction >> Growth Factors/Hormones >> TGF
Applications
Show applications key
Our Abpromise guarantee covers the use of ab55315 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
SDS-PAGE: Use at an assay dependent dilution.
Protein info
Function
Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.
Tissue specificity
Expressed in the kidney and bladder. Lower levels seen in the brain.
Sequence similarities
Belongs to the TGF-beta family.
Developmental stage
Expressed in the developing eye, brain and ear during embryogenesis.
Post-translational
modifications
Several N-termini starting at positions 293, 300, 315 and 316 have been identified by direct sequencing resulting in secretion of different mature forms (PubMed:17977014).
Cellular localization
Secreted.
Target information above from: UniProt accessionP18075
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
References for BMP7 protein (ab55315)
ab55315 has not yet been referenced specifically in any publications.
Publishing research using ab55315? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"