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Overview

  • Product nameBMP9 protein (Active)See all BMP9 proteins and peptides ...
  • Protein descriptionRecombinant fragment, corresponding to amino acids 320-429 (109 amino acids) of Human BMP9, predicted MW from sequence 12kDa (UniProt ID: Q9UK05).
  • Expression hostCHO

    • Properties

  • Purity> 95 % by SDS-PAGE
  • Purification notesPurity: Greater than 95% by SDS-PAGE gel and HPLC analyses. Endotoxin level is less than 0.1 ng per µg (1EU/µg).
  • Biological activityDetermined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 0.5-1.9 ng/ml.
  • FormLyophilised
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.This product is an active protein and may elicit a biological response in vivo, handle with caution.
  • Concentration information loading...
  • Sequence notesSAGAGSHCQK TSLRVNFEDI GWDSWIIAPK EYEAYECKGG CFFPLADDVT PTKHAIVQTL VHLKFPTKVG KACCVPTKLS PISVLYKDDM GVPTLKYHYE GMSVAECGCR
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab94350 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    SDS-PAGE
  • Application notesSDS-PAGE: Use at an assay dependent dilution.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.

    • Protein info

    • Alternative names
        BMP 9Bone morphogenetic protein 9GDF 2
        GDF2growth differentiation factor 2Growth/differentiation factor 2
      see all
  • RelevanceBMP9 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. They are regulators of cell growth and differentiation. BMP9 has a role in the maturation of BFCN (basal forebrain cholinergic neurons) also inducing and maintaining the ability of these cells to respond to acetylcholine; BFCN are important for the processes of learning, memory and attention. BMP9 is a potent inducer of hepcidin (a cationic peptide that has a antimicrobial properties) in hepatocytes and can regulate iron metabolism. The physiological receptor of BMP9 is thought to be activin receptor-like kinase 1, ALK1 (also called ACVRL1), an endothelial-specific type I receptor of the TGF-beta receptor family. BMP9 is one of the most potent BMPs to induce orthotopic bone formation in vivo. BMP3, a blocker of most BMPs seems not to affect BMP9.
  • Cellular localizationSecreted

    • References for BMP9 protein (Active) (ab94350)

    ab94350 has not yet been referenced specifically in any publications.

    Publishing research using ab94350 ? Please let us know so that we can cite the reference in this datasheet

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    Hello, I'm interested in Human BMP9 protein. I wanted to know if your product is biologically active and how do you assay its biological activity. Meaning, does it bind to its receptor and initiate signaling? Thanks!

    Thank you very much for your inquiry.

    I can confirm that ab94350 is only a fragment of the BMP9 protein.

    We have preliminary results that it is biological active. This was determined by its ability to induce alkaline phosphatase prod...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"