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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - BMPR1A antibody (ab59945)
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Western blot - BMPR1A antibody (ab59945)
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Product Name
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BMPR1A antibody
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See all BMPR1A antibodies (8)...
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Product type
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Primary antibodies
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Description
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Rabbit polyclonal to BMPR1A
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Immunogen
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Synthetic peptide (10-30 aa in length) from the N-terminus of human BMPR1A, conjugated to KLH.
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Reacts with
(species key)
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Hu
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Tested applications
(see key)
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ELISA, IHC-P, WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
ELISA: 1/1000.
IHC-P: 1/50 - 1/100.
WB: Use at a concentration of 1 µg/ml. Detects a band of approximately 60 kDa (predicted molecular weight: 60 kDa).
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Positive control
(see definition)
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Human breast carcinoma tissue.
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Cellular localization
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Cell Membrane
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Research areas
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Stem Cells >> Hematopoietic Progenitors >> Lymphoid >> B Lymphocytic Lineage
Signal Transduction >> Metabolism >> Vitamins / Minerals
Stem Cells >> Mesenchymal Stem Cells >> Surface Molecules
Stem Cells >> Signaling Pathways >> TGF beta >> Surface Molecules
Signal Transduction >> Growth Factors/Hormones >> TGF
Signal Transduction >> Protein Phosphorylation >> Ser / Thr Kinases >> Other Kinases
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Relevance
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The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.
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BMPR1A antibody (ab59945) |
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Rabbit
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Clonality
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Polyclonal
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Isotype
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IgG
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Purity
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Protein G purified
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Storage buffer
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Preservative: 0.09% Sodium Azide
Constituents: PBS Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS
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Purification notes
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ab59945 is purified through a protein G column and eluted out with both high and low pH buffers and neutralized immediately after elution then followed by dialysis against PBS.
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Form
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Liquid
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Concentration
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0.250 mg/ml
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Storage instructions
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Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this BMPR1A antibody is on this datasheet. But please do contact us if you would like any reassurance! |
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See below for BMPR1A antibody images, references, products related to ab59945 and other tools.
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BMPR1A antibody images:
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 Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - BMPR1A antibody (ab59945)
ab59945 at 1/50 - 1/100 dilution, staining BMPR1A in human breast carcinoma by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue, followed by peroxidase-conjugated secondary antibody and AEC staining.
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Search PubMed (MEDLINE) for references to BMPR1A
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BMPR1A antibody - more information
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Customer reviews (feedback) regarding BMPR1A antibody |
Customer FAQs regarding BMPR1A antibody |
Protocols for BMPR1A antibody |
Price and availability of products related to BMPR1A antibody |
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BMPR1A antibody - related products:
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BMPR1A antibody - other tools:
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Contact Abcam with a Technical Enquiry about BMPR1A antibody |
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All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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