BMPR1B antibody [MM0055-3E12] (ab78417)

Product Name 

BMPR1B antibody [MM0055-3E12]

Product type 

Primary antibodies

Description 

Mouse monoclonal [MM0055-3E12] to BMPR1B

Immunogen 

Recombinant human BMPR1B extracellular domain

Reacts with 
(species key)

Hu

Specificity 

ab78417 detects BMPR1B. No cross reactivity was found to BMPR1A (ALK3).

Tested applications 
(see key)

IHC-P, WB

Abreviews 

Customer reviews (see key)

Read about Abreviews

Application notes 
(see key)

Recommended dilutions
IHC-P: 1/50 - 1/200.
WB: 1/100 - 1/1000. Predicted molecular weight: 57 kDa.


Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Cellular localization 

Membrane; Single pass type I membrane protein.

Research areas 

Stem Cells >> Mesenchymal Stem Cells >> Surface Molecules
Stem Cells >> Signaling Pathways >> TGF beta >> Surface Molecules
Chromatin and Nuclear Signaling >> Nuclear Signaling Pathways >> SMADs
Signal Transduction >> Signaling Pathway >> Nuclear Signaling >> SMADs
Signal Transduction >> Cytoskeleton / ECM >> Extracellular Matrix >> Structures >> Bone
Signal Transduction >> Growth Factors/Hormones >> TGF
Signal Transduction >> Protein Phosphorylation >> Ser / Thr Kinases >> Other Kinases

Relevance 

The bone morphogenetic protein (BMP) receptors belong to a family of transmembrane serine/threonine kinases including the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these BMP receptors are BMPs which are members of the TGF-beta superfamily. BMPs transduce their signals through the formation of heteromeric complexes with 2 different types of serine/threonine kinase receptors. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. BMP receptors are highly expressed in bone, skeletal muscle, heart and liver tissue. BMPRs play a crucial role during development as mutations or deletions to the BMPR genes can cause juvenile polyposis, disrupt normal dorsal/ventral patterning during limb development, and may be a factor in the progession of Cowden-like syndrome. BMPR1B is a receptor for BMPS/OP-1. Mutations in BMPR1B have been associated with primary pulmonary hypertension.

Database links 

Raised in 

Mouse

Clonality 

Monoclonal

Clone number 

MM0055-3E12

Isotype 

IgG2

Purity 

Protein G purified

Storage buffer 

Preservative: None
Constituents: PBS

Purification notes 

The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and lyophilized from a 0.2 µm filtered solution in
phosphate buffered saline (PBS).

Form 

Liquid

Concentration 

0.200 mg/ml

Storage instructions 

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

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