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Western blot - BMPR1B antibody (ab54907)
(enlarge)
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Product Name
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BMPR1B antibody
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See all BMPR1B antibodies (3)...
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Product type
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Primary antibodies
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Description
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Mouse monoclonal to BMPR1B
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Immunogen
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Recombinant full length protein, corresponding to amino acids 14-503 of Human BMPR1B
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Reacts with
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RecFrag
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Predicted to react
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Hu
(Due to sequence homology)
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Tested applications
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WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
WB: Use at a concentration of 1-5 µg/ml.
This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Membrane; Single pass type I membrane protein.
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Research areas
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Stem Cells >> Mesenchymal Stem Cells >> Surface Molecules
Stem Cells >> Signaling Pathways >> TGF beta >> Surface Molecules
Chromatin and Nuclear Signaling >> Nuclear Signaling Pathways >> SMADs
Signal Transduction >> Signaling Pathway >> Nuclear Signaling >> SMADs
Signal Transduction >> Cytoskeleton / ECM >> Extracellular Matrix >> Structures >> Bone
Signal Transduction >> Growth Factors/Hormones >> TGF
Signal Transduction >> Protein Phosphorylation >> Ser / Thr Kinases >> Other Kinases
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Relevance
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The bone morphogenetic protein (BMP) receptors belong to a family of transmembrane serine/threonine kinases including the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these BMP receptors are BMPs which are members of the TGF-beta superfamily. BMPs transduce their signals through the formation of heteromeric complexes with 2 different types of serine/threonine kinase receptors. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. BMP receptors are highly expressed in bone, skeletal muscle, heart and liver tissue. BMPRs play a crucial role during development as mutations or deletions to the BMPR genes can cause juvenile polyposis, disrupt normal dorsal/ventral patterning during limb development, and may be a factor in the progession of Cowden-like syndrome. BMPR1B is a receptor for BMPS/OP-1. Mutations in BMPR1B have been associated with primary pulmonary hypertension.
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BMPR1B antibody (ab54907) |
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Mouse
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Clonality
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Monoclonal
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Isotype
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IgG1
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Light chain type
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kappa
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Purity
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Protein G purified
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Storage buffer
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Preservative: None
PBS, pH 7.2
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Form
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Liquid
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Concentration
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1.000 mg/ml
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Storage instructions
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this BMPR1B antibody is on this datasheet. But please do contact us if you would like any reassurance! |
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See below for BMPR1B antibody images, references, products related to ab54907 and other tools.
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BMPR1B antibody images:
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 Western blot - BMPR1B antibody (ab54907)
Western blot against tagged recombinant protein immunogen using ab54907 BMPR1B antibody at 1ug/ml. Predicted band size of immunogen is 80 kDa. This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.
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Search PubMed (MEDLINE) for references to BMPR1B
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BMPR1B antibody - more information
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Customer reviews (feedback) regarding BMPR1B antibody |
Customer FAQs regarding BMPR1B antibody |
Protocols for BMPR1B antibody |
Price and availability of products related to BMPR1B antibody |
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BMPR1B antibody - related products:
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BMPR1B antibody - other tools:
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Contact Abcam with a Technical Enquiry about BMPR1B antibody |
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All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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