|
|
|
|
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - BMPR2 antibody [MM0060-9A10] (ab78422)
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - BMPR2 antibody [MM0060-9A10] (ab78422)](/ps/datasheet/images/78/ab78422/BMPR2-Primary-antibodies-ab78422-1.jpg)
(enlarge)
|
|
|
|
|
Product Name
|
BMPR2 antibody [MM0060-9A10]
|
| |
See all BMPR2 antibodies (2)...
|
|
Product type
|
Primary antibodies
|
|
Description
|
Mouse monoclonal [MM0060-9A10] to BMPR2
|
|
Immunogen
|
Recombinant human BMPR2 extracellular domain
|
|
Reacts with
(species key)
|
Hu
|
|
Specificity
|
ab78422 detects BMPR2. No cross reactivity was found to BMPR1A and BMPR1B.
|
|
Tested applications
(see key)
|
IHC-P, WB
|
|
|
Abreviews
|
|
|
|
Application notes
(see key)
|
Recommended dilutions
IHC-P: 1/50 - 1/200.
WB: 1/100 - 1/1000. Predicted molecular weight: 115 kDa.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
|
|
Cellular localization
|
Membrane; Single-pass type I membrane protein.
|
|
Research areas
|
Cardiovascular >> Heart >> Hypertrophy >> Other
Stem Cells >> Mesenchymal Stem Cells >> Surface Molecules
Stem Cells >> Signaling Pathways >> TGF beta >> Surface Molecules
Signal Transduction >> Cytoskeleton / ECM >> Extracellular Matrix >> Structures >> Bone
Signal Transduction >> Growth Factors/Hormones >> TGF
Signal Transduction >> Protein Phosphorylation >> Ser / Thr Kinases >> Other Kinases
|
|
Relevance
|
The bone morphogenetic protein (BMP) receptors belong to a family of transmembrane serine/threonine kinases including the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. Both activins and TGF-beta transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors. BMPRs play a crucial role during development as mutations or deletions to the BMPR genes can cause juvenile polyposis, disrupt normal dorsal/ventral patterning during limb development, and may be a factor in the progession of Cowden-like syndrome. Germline mutations in the BMPR2 gene encoding bone morphogenetic protein (BMP) type II receptor (BMPR-II) have been reported in patients with primary pulmonary hypertension (PPH).
|
|
|
BMPR2 antibody [MM0060-9A10] (ab78422) |
|
Database links
|
The links below go to external sites and will open in a new browser window |
|
Raised in
|
Mouse
|
|
Clonality
|
Monoclonal
|
|
Clone number
|
MM0060-9A10
|
|
Isotype
|
IgG1
|
|
Purity
|
Protein G purified
|
|
Storage buffer
|
Preservative: None
Constituents: PBS
|
|
Purification notes
|
The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and lyophilized from a 0.2 µm filtered solution in phosphate buffered saline (PBS).
|
|
Form
|
Liquid
|
|
Concentration
|
0.200 mg/ml
|
|
Storage instructions
|
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
|
| |
At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this BMPR2 antibody [MM0060-9A10] is on this datasheet. But please do contact us if you would like any reassurance! |
 |
|
|
See below for BMPR2 antibody [MM0060-9A10] images, references, products related to ab78422 and other tools.
|
| |
BMPR2 antibody [MM0060-9A10] images:
|
 Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - BMPR2 antibody [MM0060-9A10] (ab78422)
ab78422 at 1/200 dilution, staining BMPR2 in human placental tissue section by Immunohistochemistry (Formalin/PFA fixed paraffin-embedded sections).
|
| |
| |
|
Search PubMed (MEDLINE) for references to BMPR2
|
| |
BMPR2 antibody [MM0060-9A10] - more information
|
Customer reviews (feedback) regarding BMPR2 antibody [MM0060-9A10] |
Customer FAQs regarding BMPR2 antibody [MM0060-9A10] |
Protocols for BMPR2 antibody [MM0060-9A10] |
Price and availability of products related to BMPR2 antibody [MM0060-9A10] |
| |
BMPR2 antibody [MM0060-9A10] - related products:
|
|
|
| |
BMPR2 antibody [MM0060-9A10] - other tools:
|
Contact Abcam with a Technical Enquiry about BMPR2 antibody [MM0060-9A10] |
| |
All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
Pricing information loading
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - BMPR2 antibody [MM0060-9A10] (ab78422)](/index.html?datasheet=78422#BMPR2-Primary-antibodies-ab78422-1.jpg)
