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Products:Signal Transduction >> Protein Phosphorylation >> Tyrosine Kinases >> Other
Overview
Product name
Anti-BMX antibody
See all BMX products (8) ...
Description
Rabbit polyclonal to BMX
Tested applications
ELISA, IHC-Pmore details
Cross reactivity
Reacts with
Mouse, Human
Immunogen
Synthetic non-phosphopeptide derived from human ETK around the phosphorylation site of tyrosine 40 (L-S-YP-Y-E).
Positive control
Human skin.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer
Preservative: 0.02% Sodium Azide
Constituents: 50% Glycerol, PBS (without Mg2+ and Ca2+), 150mM Sodium chloride, pH 7.4
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Signal Transduction >> Protein Phosphorylation >> Tyrosine Kinases >> Other
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Immunohistochemistry (Paraffin-embedded sections) - BMX antibody (ab59288)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab59288 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ELISA
ELISA: 1/5000ELISA: 1/5000
IHC-P: 1/50 - 1/100.
Target
Function
Activity is required for interleukin 6 (IL-6) induced differentiation. May play a role in the growth and differentiation of hematopoietic cells. May be involved in signal transduction in endocardial and arterial endothelial cells.
Tissue specificity
Preferentially expressed in epithelial and endothelial cells.
Sequence similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily.
Contains 1 Btk-type zinc finger.
Contains 1 PH domain.
Contains 1 protein kinase domain.
Contains 1 SH2 domain.
Domain
SH2 domain mediates interaction with RUFY1.
Cellular localization
Cytoplasm.
Target information above from: UniProt accessionP51813
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- Bone marrow tyrosine kinase gene in chromosome X protein antibody
- Bmx antibody
- BMX non receptor tyrosine kinase antibody
see all
Database links
- Entrez Gene: 660 Human
- Entrez Gene: 12169 Mouse
- Omim: 300101 Human
- SwissProt: P51813 Human
- SwissProt: P97504 Mouse
- Unigene: 495731 Human
- Unigene: 504 Mouse
Anti-BMX antibody images:
Immunohistochemistry (Paraffin-embedded sections) - BMX antibody (ab59288)
Ab59288 at 1/50 dilution staining human skin tissue without (left) and with (right) immunizing peptide; paraffin embedded.
References for Anti-BMX antibody (ab59288)
This product has been referenced in:
- Guryanova OAet al. Nonreceptor Tyrosine Kinase BMX Maintains Self-Renewal and Tumorigenic Potential of Glioblastoma Stem Cells by Activating STAT3. Cancer Cell 19:498-511 (2011). WB, ICC/IF; Mouse.Read more (PubMed: 21481791) »
See 1 publication for this product
Publishing research using ab59288? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"