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Products:Signal Transduction >> Protein Phosphorylation >> Tyrosine Kinases >> Other
Overview
Product name
Anti-BMX (phospho Y40) antibody
See all BMX products (8) ...
Description
Rabbit polyclonal to BMX (phospho Y40)
Specificity
Detects endogenous levels of ETK only when phosphorylated at tyrosine 40.
Tested applications
ELISA, IHC-Pmore details
Cross reactivity
Reacts with
Mouse, Human
Immunogen
Synthetic phosphopeptide derived from human ETK around the phosphorylation site of tyrosine 40 (L-S-YP-Y-E).
Positive control
Human skin tissue
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer
Preservative: 0.02% Sodium Azide
Constituents: 50% Glycerol, PBS (without Mg2+ and Ca2+), 150mM Sodium chloride, pH 7.4
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Purification notes
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide.The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Clonality
Polyclonal
Isotype
IgG
Research areas
Signal Transduction >> Protein Phosphorylation >> Tyrosine Kinases >> Other
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Immunohistochemistry (Paraffin-embedded sections) - BMX (phospho Y40) antibody (ab59304)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab59304 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ELISA
ELISA: 1/40000ELISA: 1/40000
IHC-P: 1/50 - 1/100.
Target
Function
Activity is required for interleukin 6 (IL-6) induced differentiation. May play a role in the growth and differentiation of hematopoietic cells. May be involved in signal transduction in endocardial and arterial endothelial cells.
Tissue specificity
Preferentially expressed in epithelial and endothelial cells.
Sequence similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily.
Contains 1 Btk-type zinc finger.
Contains 1 PH domain.
Contains 1 protein kinase domain.
Contains 1 SH2 domain.
Domain
SH2 domain mediates interaction with RUFY1.
Cellular localization
Cytoplasm.
Target information above from: UniProt accessionP51813
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- Bone marrow tyrosine kinase gene in chromosome X protein antibody
- Bmx antibody
- BMX non receptor tyrosine kinase antibody
see all
Database links
- Entrez Gene: 660 Human
- Entrez Gene: 12169 Mouse
- Omim: 300101 Human
- SwissProt: P51813 Human
- SwissProt: P97504 Mouse
- Unigene: 495731 Human
- Unigene: 504 Mouse
Anti-BMX (phospho Y40) antibody images:
Immunohistochemistry (Paraffin-embedded sections) - BMX (phospho Y40) antibody (ab59304)
Ab59304 at 1/50-1/100 dilution staining human skin tissue without (left) and with (right) immunizing peptide; paraffin embedded.
References for Anti-BMX (phospho Y40) antibody (ab59304)
ab59304 has not yet been referenced specifically in any publications.
Publishing research using ab59304? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"