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Western blot - BRIT1 antibody (ab57751)
Western blot - BRIT1 antibody (ab57751)
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Product Name 

BRIT1 antibody

 

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Product type 

Primary antibodies

Description 

Mouse monoclonal to BRIT1

Immunogen 

Recombinant fragment: ATSSCVTSAP EEALRCCRQA GKEDACPEGN GFSYTIEDPA LPKGHDDDLT PLEGSLEEMK EAVGLKSTQN KGTTSKISNS SEGEAQSEH, corresponding to amino acids 399-488 of Human BRIT1
BLAST 'ATSSCVTSAP EEALRCCRQA GKEDACPEGN GFSYTIEDPA LPKGHDDDLT PLEGSLEEMK EAVGLKSTQN KGTTSKISNS ' with BLAST the sequence with ExPASy or BLAST the sequence with NCBI

Reacts with 
(species key)

Hu

Tested applications 
(see key)

WB


Abreviews 

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Application notes 
(see key)

Recommended dilutions
WB: Use at a concentration of 1-5 µg/ml.

This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Cellular localization 

Centrosome.

Research areas 

Chromatin and Nuclear Signaling >> DNA / RNA >> DNA Damage & Repair >> DNA Damage Response >> BRCT Domain Proteins

Relevance 

BRIT1 (BRCT-repeat inhibitor of hTERT expression) contains two BRCT domains in the C terminus. It was identified in a screen for negative regulators of hTERT (human telomerase) expression. It has been implicated in chromosome condensation and DNA damage induced cellular responses. It may play a role in neurogenesis and regulation of the size of the cerebral cortex. Defects in BRIT1 are the cause of primary microcephaly 1 (MCPH1)

 

BRIT1 antibody (ab57751)

Database links 

The links below go to external sites and will open in a new browser window

Entrez Gene

    

79648    (Human)

NCBI

    

NP_078872    (Human)

Omim

    

607117    (Human)

SwissProt

    

Q9H9C7    (Human)

Raised in 

Mouse

Clonality 

Monoclonal

Isotype 

IgG1

Light chain type 

kappa

Purity 

Protein G purified

Storage buffer 

Preservative: None
PBS, pH 7.2

Form 

Liquid

Concentration 

1.000 mg/ml

Storage instructions 

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

 

At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this BRIT1 antibody is on this datasheet. But please do contact us if you would like any reassurance!


 

BRIT1 antibody images:

Product image  Western blot - BRIT1 antibody (ab57751)

Western blot - BRIT1 antibody (ab57751)

Western blot against tagged recombinant protein immunogen using ab57751 BRIT1 antibody at 1ug/ml. Predicted band size of immunogen is 36 kDa

 
 

Search PubMed (MEDLINE) for references to BRIT1

 

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