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Anti-BRIT1 antibody (ab57751)

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Overview

Product name

Anti-BRIT1 antibody
See all BRIT1 products (4) ...

Description

Mouse monoclonal to BRIT1

Tested applications

WBmore details

Cross reactivity

Reacts with

Human

Immunogen

Recombinant fragment: ATSSCVTSAP EEALRCCRQA GKEDACPEGN GFSYTIEDPA LPKGHDDDLT PLEGSLEEMK EAVGLKSTQN KGTTSKISNS SEGEAQSEH, corresponding to amino acids 399-488 of Human BRIT1

ATSSCVTSAP EEALRCCRQA GKEDACPEGN GFSYTIEDPA LPKGHDDDLT PLEGSLEEMK EAVGLKSTQN KGTTSKISNS SEGEAQSEH

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: None
PBS, pH 7.2

Concentration

Concentration information loading...

Purity

Protein G purified

Clonality

Monoclonal

Isotype

IgG1

Light chain type

kappa

  • Western blot - BRIT1 antibody (ab57751)Western blot - BRIT1 antibody (ab57751) image (enlarge)

Applications

Show applications key

Our Abpromise guarantee covers the use of ab57751 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application notes

WB: Use at a concentration of 1-5 µg/ml.

This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Target

Function

Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex.

Tissue specificity

Expressed in fetal brain, liver and kidney.

Involvement in disease

Defects in MCPH1 are the cause of microcephaly primary type 1 (MCPH1) [MIM:251200]; also known as true microcephaly or microcephaly vera. Microcephaly is defined as a head circumference more than 3 standard deviations below the age-related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. Despite this marked reduction in size, the gyral pattern is relatively well preserved, with no major abnormality in cortical architecture. Primary microcephaly is further defined by the absence of other syndromic features or significant neurological deficits. This entity is inherited as autosomal recessive trait.

Sequence similarities

Contains 3 BRCT domains.

Cellular localization

Cytoplasm > cytoskeleton > centrosome.

Target information above from: UniProt accessionQ8NEM0 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • BRCT repeat inhibitor of TERT expression 1 antibody
  • BRIT 1 antibody
  • FLJ12847 antibody
  • Hypothetical protein FLJ12847 antibody
  • Hypothetical protein FLJ12847 antibody
  • MCPH 1 antibody
  • MCPH 1 antibody
  • MCPH1 antibody
  • MCPH1_HUMAN antibody
  • MCT antibody
  • Microcephalin antibody
  • Microcephaly primary autosomal recessive 1 antibody
see all

Anti-BRIT1 antibody images:

  Western blot - BRIT1 antibody (ab57751)

Western blot - BRIT1 antibody (ab57751)

Western blot against tagged recombinant protein immunogen using ab57751 BRIT1 antibody at 1ug/ml. Predicted band size of immunogen is 36 kDa

References for Anti-BRIT1 antibody (ab57751)

ab57751 has not yet been referenced specifically in any publications.

Publishing research using ab57751? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"