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Products:Epigenetics and Nuclear Signaling >> DNA / RNA >> DNA Damage & Repair >> DNA Damage Response >> BRCT Domain Proteins
Overview
Product name
Anti-BRIT1 antibody
See all BRIT1 products (4) ...
Description
Mouse monoclonal to BRIT1
Tested applications
Cross reactivity
Reacts with
Human
Immunogen
Recombinant fragment: ATSSCVTSAP EEALRCCRQA GKEDACPEGN GFSYTIEDPA LPKGHDDDLT PLEGSLEEMK EAVGLKSTQN KGTTSKISNS SEGEAQSEH, corresponding to amino acids 399-488 of Human BRIT1
ATSSCVTSAP EEALRCCRQA GKEDACPEGN GFSYTIEDPA LPKGHDDDLT PLEGSLEEMK EAVGLKSTQN KGTTSKISNS SEGEAQSEH
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
PBS, pH 7.2
Concentration
Concentration information loading...
Purity
Protein G purified
Clonality
Monoclonal
Isotype
IgG1
Light chain type
kappa
Research areas
Epigenetics and Nuclear Signaling >> DNA / RNA >> DNA Damage & Repair >> DNA Damage Response >> BRCT Domain Proteins
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Western blot - BRIT1 antibody (ab57751)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab57751 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- 1 Image
WB
Application notes
WB: Use at a concentration of 1-5 µg/ml.
This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Function
Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex.
Tissue specificity
Expressed in fetal brain, liver and kidney.
Involvement in disease
Defects in MCPH1 are the cause of microcephaly primary type 1 (MCPH1) [MIM:251200]; also known as true microcephaly or microcephaly vera. Microcephaly is defined as a head circumference more than 3 standard deviations below the age-related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. Despite this marked reduction in size, the gyral pattern is relatively well preserved, with no major abnormality in cortical architecture. Primary microcephaly is further defined by the absence of other syndromic features or significant neurological deficits. This entity is inherited as autosomal recessive trait.
Sequence similarities
Contains 3 BRCT domains.
Cellular localization
Cytoplasm > cytoskeleton > centrosome.
Target information above from: UniProt accessionQ8NEM0
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- BRCT repeat inhibitor of TERT expression 1 antibody
- BRIT 1 antibody
- FLJ12847 antibody
see all
Database links
- Entrez Gene: 79648 Human
- NCBI: 13375793 Human
- Omim: 607117 Human
- SwissProt: Q8NEM0 Human
- Unigene: 656769 Human
- Unigene: 708770 Human
- Unigene: 721952 Human
Anti-BRIT1 antibody images:
Western blot - BRIT1 antibody (ab57751)
Western blot against tagged recombinant protein immunogen using ab57751 BRIT1 antibody at 1ug/ml. Predicted band size of immunogen is 36 kDa
References for Anti-BRIT1 antibody (ab57751)
ab57751 has not yet been referenced specifically in any publications.
Publishing research using ab57751? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"