Bag3 antibody (ab56739)

Product Name 

Bag3 antibody

Product type 

Primary antibodies

Description 

Mouse monoclonal to Bag3

Immunogen 

Recombinant full length protein, corresponding to amino acids 1-576 of Human Bag3

Reacts with 
(species key)

Hu

Tested applications 
(see key)

WB

Abreviews 

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Application notes 
(see key)

Recommended dilutions
WB: Use at a concentration of 1-5 µg/ml.

This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Research areas 

Cancer >> Invasion/microenvironment >> Apoptosis >> Bcl 2 family
Cell Biology >> Apoptosis >> Intracellular >> Bcl2 Family

Relevance 

BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45 amino acid BAG domain near the C terminus but differ markedly in their N terminal regions. The protein encoded by this gene contains a WW domain in the N terminal region and a BAG domain in the C terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip repressible manner.

Database links 

Raised in 

Mouse

Clonality 

Monoclonal

Isotype 

IgG2b

Light chain type 

kappa

Purity 

Protein G purified

Storage buffer 

Preservative: None
PBS, pH 7.2

Form 

Liquid

Concentration 

1.000 mg/ml

Storage instructions 

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

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