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Products:Cell Biology >> Apoptosis >> Intracellular >> Bcl2 Family
Overview
Product name
Anti-Bag3 antibody
See all Bag3 products (7) ...
Description
Mouse monoclonal to Bag3
Tested applications
Cross reactivity
Reacts with
Human
Immunogen
Recombinant full length protein, corresponding to amino acids 1-576 of Human Bag3
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
PBS, pH 7.2
Concentration
Concentration information loading...
Purity
Protein G purified
Clonality
Monoclonal
Isotype
IgG2b
Light chain type
kappa
Research areas
Cancer >> Invasion/microenvironment >> Apoptosis >> Bcl 2 family
Cell Biology >> Apoptosis >> Intracellular >> Bcl2 Family
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Western blot - Bag3 antibody (ab56739)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab56739 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- 1 Image
WB
Application notes
WB: Use at a concentration of 1-5 µg/ml.
This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Function
Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity.
Involvement in disease
Defects in BAG3 are the cause of myopathy myofibrillar BAG3-related (MFM-BAG3) [MIM:612954]. A neuromuscular disorder that results in early-onset, severe, progressive, diffuse muscle weakness associated with cardiomyopathy, severe respiratory insufficiency during adolescence, and a rigid spine in some patients. At ultrastructural level, muscle fibers display structural alterations consisting of replacement of the normal myofibrillar markings by small, dense granules, or larger hyaline masses, or amorphous material.
Sequence similarities
Contains 1 BAG domain.
Contains 2 WW domains.
Target information above from: UniProt accessionO95817
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- BAG 3 antibody
- BAG 3 antibody
- BAG family molecular chaperone regulator 3 antibody
see all
Database links
- Entrez Gene: 9531 Human
- Omim: 603883 Human
- SwissProt: O95817 Human
- Unigene: 15259 Human
- Unigene: 523309 Human
Anti-Bag3 antibody images:
Western blot - Bag3 antibody (ab56739)
Western blot against tagged recombinant protein immunogen using ab56739 Bag3 antibody at 1ug/ml. Predicted band size of immunogen is 89 kDa
References for Anti-Bag3 antibody (ab56739)
ab56739 has not yet been referenced specifically in any publications.
Publishing research using ab56739? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"