Batimastat (BB-94), Matrix metalloprotease (MMP) inhibitor (ab142087)
Key features and details
- Potent, broad-spectrum MMP inhibitor
- CAS Number: 130370-60-4
- Purity: > 98%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Batimastat (BB-94), Matrix metalloprotease (MMP) inhibitor -
Description
Potent, broad-spectrum MMP inhibitor -
Biological description
Potent, broad-spectrum MMP inhibitor (IC50 values are 3 (MMP-1), 4 (MMP-2), 4 (MMP-9), 6 (MMP-7), 20 nM (MMP-3)). Anticancer activity in vivo.
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Purity
> 98% -
CAS Number
130370-60-4 -
Chemical structure
Properties
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Chemical name
(2R,3S)-N4-Hydroxy-N1-[(1S)-2-(methylamino)-2-oxo-1-(phenylmethyl)ethyl]-2-(2-methylpropyl)-3-[(2-thienylthio)methyl]butanediamide -
Molecular weight
477.64 -
Molecular formula
C23H31N3O4S2 -
PubChem identifier
5362422 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(C)CC(C(CSC1=CC=CS1)C(=O)NO)C(=O)NC(CC2=CC=CC=C2)C(=O)NC -
Source
Synthetic
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Research areas
Images
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (7)
ab142087 has been referenced in 7 publications.
- Brauer E et al. Dissecting the influence of cellular senescence on cell mechanics and extracellular matrix formation in vitro. Aging Cell 22:e13744 (2023). PubMed: 36514868
- Keppie SJ et al. Matrix-Bound Growth Factors are Released upon Cartilage Compression by an Aggrecan-Dependent Sodium Flux that is Lost in Osteoarthritis. Function (Oxf) 2:zqab037 (2021). PubMed: 34423304
- Ambite I et al. Molecular Basis of Acute Cystitis Reveals Susceptibility Genes and Immunotherapeutic Targets. PLoS Pathog 12:e1005848 (2016). PubMed: 27732661
- Paschkowsky S et al. Alternative Processing of the Amyloid Precursor Protein Family by Rhomboid Protease RHBDL4. J Biol Chem 291:21903-21912 (2016). PubMed: 27563067
- McColl R et al. Analysis and quantification of in vitro myoblast fusion using the LADD Multiple Stain. Biotechniques 61:323-326 (2016). PubMed: 27938324
- Cremasco V et al. B cell homeostasis and follicle confines are governed by fibroblastic reticular cells. Nat Immunol 15:973-81 (2014). PubMed: 25151489
- Beltramo E et al. Extracellular vesicles derived from mesenchymal stem cells induce features of diabetic retinopathy in vitro. Acta Diabetol 51:1055-64 (2014). PubMed: 25374383