Validated using a knockout cell line

Anti-Bcl-2 antibody [E17] (ab32124)

Publishing research using ab32124? Please let us know so that we can cite the reference in this datasheet.

ab32124 has been referenced in 70 publications.

  • Sun Y  et al. Therapeutic effect of apocynin through antioxidant activity and suppression of apoptosis and inflammation after spinal cord injury. Exp Ther Med 13:952-960 (2017). WB ; Rat . PubMed: 28450925
  • Zhang Z  et al. Sepia ink oligopeptide induces apoptosis and growth inhibition in human lung cancer cells. Oncotarget 8:23202-23212 (2017). WB ; Human . PubMed: 28423568
  • Zhang C  et al. Growth of tyrosine kinase inhibitor-resistant Philadelphia-positive acute lymphoblastic leukemia: Role of bone marrow stromal cells. Oncol Lett 13:2059-2070 (2017). WB . PubMed: 28454362
  • Gai P  et al. miR-22 promotes apoptosis of osteosarcoma cells via inducing cell cycle arrest. Oncol Lett 13:2354-2358 (2017). WB ; Human . PubMed: 28454403
  • Ma L  et al. Long non-coding RNA XIST promotes cell growth and invasion through regulating miR-497/MACC1 axis in gastric cancer. Oncotarget 8:4125-4135 (2017). WB ; Human . PubMed: 27911852
  • Zhang FQ  et al. Regulation of c-Jun N-Terminal Protein Kinase (JNK) Pathway in Apoptosis of Endothelial Outgrowth Cells Induced by Asymmetric Dimethylarginine. Med Sci Monit 23:2535-2542 (2017). WB ; Human . PubMed: 28546532
  • Patel N  et al. miR-15a/miR-16 down-regulates BMI1, impacting Ub-H2A mediated DNA repair and breast cancer cell sensitivity to doxorubicin. Sci Rep 7:4263 (2017). WB ; Human . PubMed: 28655885
  • Wu C  et al. Smoothened antagonist GDC-0449 (Vismodegib) inhibits proliferation and triggers apoptosis in colon cancer cell lines. Exp Ther Med 13:2529-2536 (2017). PubMed: 28565875
  • Yan H  et al. Grifolin induces apoptosis and promotes cell cycle arrest in the A2780 human ovarian cancer cell line via inactivation of the ERK1/2 and Akt pathways. Oncol Lett 13:4806-4812 (2017). WB . PubMed: 28588729
  • Chen Y  et al. Proliferation and invasion of ovarian cancer cells are suppressed by knockdown of TRIM11. Oncol Lett 14:2125-2130 (2017). PubMed: 28781653
  • Deng YP  et al. Human bocavirus induces apoptosis and autophagy in human bronchial epithelial cells. Exp Ther Med 14:753-758 (2017). PubMed: 28672995
  • Cheng J  et al. Role of nuclear factor (erythroid-derived 2)-like 2 in the age-resistant properties of the glaucoma trabecular meshwork. Exp Ther Med 14:791-796 (2017). PubMed: 28673001
  • Du H  et al. Pre-treatment with spermine for acute cerebral ischemia/reperfusion injuries. Exp Ther Med 14:169-172 (2017). PubMed: 28672910
  • Wang C  et al. Neuroprotective mechanisms of miR-124 activating PI3K/Akt signaling pathway in ischemic stroke. Exp Ther Med 13:3315-3318 (2017). WB . PubMed: 28587406
  • Wang S  et al. Effect and mechanism of resveratrol on drug resistance in human bladder cancer cells. Mol Med Rep 15:1179-1187 (2017). PubMed: 28098863
  • Shi X  et al. The involvement and possible mechanism of NR4A1 in chondrocyte apoptosis during osteoarthritis. Am J Transl Res 9:746-754 (2017). PubMed: 28337303
  • Jiang Y  et al. microRNA-383 mediates high glucose-induced oxidative stress and apoptosis in retinal pigment epithelial cells by repressing peroxiredoxin 3. Am J Transl Res 9:2374-2383 (2017). PubMed: 28559987
  • Xiao J  et al. Efficacy and tolerability of chemotherapy in Chinese patients with AIDS-related Burkitt lymphoma and diffuse large B-cell lymphoma: An observational study. Sci Rep 7:1905 (2017). PubMed: 28507339
  • Liu Y  et al. Effects of bufalin on the mTOR/p70S6K pathway and apoptosis in esophageal squamous cell carcinoma in nude mice. Int J Mol Med 40:357-366 (2017). PubMed: 28656204
  • Woo Y  et al. Suppression of Nrf2 Activity by Chestnut Leaf Extract Increases Chemosensitivity of Breast Cancer Stem Cells to Paclitaxel. Nutrients 9:N/A (2017). PubMed: 28718813
  • Zhang Z  et al. Telomerase reverse transcriptase promotes chemoresistance by suppressing cisplatin-dependent apoptosis in osteosarcoma cells. Sci Rep 7:7070 (2017). PubMed: 28765565
  • Yu J  et al. miR-340 Inhibits Proliferation and Induces Apoptosis in Gastric Cancer Cell Line SGC-7901, Possibly via the AKT Pathway. Med Sci Monit 23:71-77 (2017). PubMed: 28057912
  • Hou H  et al. Brahma-related gene 1 induces apoptosis in a p53-dependent manner in human rheumatoid fibroblast-like synoviocyte MH7A. Medicine (Baltimore) 95:e5241 (2016). PubMed: 28002318
  • Zhang H  et al. Lymphocyte-specific protein 1 inhibits the growth of hepatocellular carcinoma by suppressing ERK1/2 phosphorylation. FEBS Open Bio 6:1227-1237 (2016). PubMed: 28255535
  • Zhu Y  et al. Baicalin Inhibits Renal Cell Apoptosis and Protects Against Acute Kidney Injury in Pediatric Sepsis. Med Sci Monit 22:5109-5115 (2016). PubMed: 28013315
  • Shen H  et al. Lin28A activates androgen receptor via regulation of c-myc and promotes malignancy of ER-/Her2+ breast cancer. Oncotarget 7:60407-60418 (2016). WB . PubMed: 27494865
  • Hou Y  et al. Mitochondria-targeted peptide SS-31 attenuates renal injury via an antioxidant effect in diabetic nephropathy. Am J Physiol Renal Physiol 310:F547-59 (2016). PubMed: 26719366
  • Fang Q  et al. Long Non-Coding RNA (LncRNA) Urothelial Carcinoma Associated 1 (UCA1) Increases Multi-Drug Resistance of Gastric Cancer via Downregulating miR-27b. Med Sci Monit 22:3506-3513 (2016). WB ; Human . PubMed: 27694794
  • Nie HF  et al. Effects of ZNF139 on gastric cancer cells and mice with gastric tumors. Oncol Lett 12:2550-2554 (2016). WB ; Human . PubMed: 27698826
  • Wang LL  et al. Suppressive effect of microRNA-143 in retinoblastoma. Int J Ophthalmol 9:1584-1590 (2016). WB ; Human . PubMed: 27990360
  • Tao J  et al. Tea polyphenols protect against ischemia/reperfusion-induced liver injury in mice through anti-oxidative and anti-apoptotic properties. Exp Ther Med 12:3433-3439 (2016). WB ; Mouse . PubMed: 27882175
  • Liu GH  et al. MicroRNA-524-5p suppresses the growth and invasive abilities of gastric cancer cells. Oncol Lett 11:1926-1932 (2016). PubMed: 26998102
  • Wang Y  et al. Tricholoma matsutake Aqueous Extract Induces Hepatocellular Carcinoma Cell Apoptosis via Caspase-Dependent Mitochondrial Pathway. Biomed Res Int 2016:9014364 (2016). WB . PubMed: 28018916
  • Chen B  et al. Inhibition of miR-29c promotes proliferation, and inhibits apoptosis and differentiation in P19 embryonic carcinoma cells. Mol Med Rep 13:2527-35 (2016). WB ; Mouse . PubMed: 26848028
  • Yang K  et al. Effect of PLCe gene silencing on inhibiting the cancerous transformation of ulcerative colitis. Exp Ther Med 12:422-426 (2016). WB ; Mouse . PubMed: 27347072
  • Qi L  et al. Cytotoxicity and genotoxicity of bacterial magnetosomes against human retinal pigment epithelium cells. Sci Rep 6:26961 (2016). WB ; Human . PubMed: 27246808
  • Gao ZY  et al. Metformin induces apoptosis via a mitochondria-mediated pathway in human breast cancer cells in vitro. Exp Ther Med 11:1700-1706 (2016). Human . PubMed: 27168791
  • Chen Y  et al. Hydroquinone-induced malignant transformation of TK6 cells by facilitating SIRT1-mediated p53 degradation and up-regulating KRAS. Toxicol Lett 259:133-42 (2016). WB ; Human . PubMed: 27515134
  • Patel N  et al. miR-15a/miR-16 induces mitochondrial dependent apoptosis in breast cancer cells by suppressing oncogene BMI1. Life Sci 164:60-70 (2016). WB . PubMed: 27596816
  • Cao LH  et al. Morphine, a potential antagonist of cisplatin cytotoxicity, inhibits cisplatin-induced apoptosis and suppression of tumor growth in nasopharyngeal carcinoma xenografts. Sci Rep 6:18706 (2016). WB ; Human . PubMed: 26729257
  • Yang W  et al. Coronary-Heart-Disease-Associated Genetic Variant at the COL4A1/COL4A2 Locus Affects COL4A1/COL4A2 Expression, Vascular Cell Survival, Atherosclerotic Plaque Stability and Risk of Myocardial Infarction. PLoS Genet 12:e1006127 (2016). WB ; Human . PubMed: 27389912
  • Chang YJ  et al. Glucose-regulated protein 78 mediates the therapeutic efficacy of 17-DMAG in colon cancer cells. Tumour Biol 36:4367-76 (2015). PubMed: 25618598
  • Hearn JM  et al. Potent organo-osmium compound shifts metabolism in epithelial ovarian cancer cells. Proc Natl Acad Sci U S A 112:E3800-5 (2015). Human . PubMed: 26162681
  • Wang X  et al. Synergistic control of sex hormones by 17ß-HSD type 7: a novel target for estrogen-dependent breast cancer. J Mol Cell Biol 7:568-79 (2015). PubMed: 25966904
  • He X  et al. Functional repair of p53 mutation in colorectal cancer cells using trans-splicing. Oncotarget 6:2034-45 (2015). Human . PubMed: 25576916
  • Srinivas C  et al. Novel Etoposide Analogue Modulates Expression of Angiogenesis Associated microRNAs and Regulates Cell Proliferation by Targeting STAT3 in Breast Cancer. PLoS One 10:e0142006 (2015). WB ; Human . PubMed: 26551008
  • do Nascimento CC  et al. Analysis of male reproductive parameters in a murine model of mucopolysaccharidosis type I (MPS I). Int J Clin Exp Pathol 7:3488-97 (2014). IHC-P ; Mouse . PubMed: 25031781
  • Némati F  et al. Targeting Bcl-2/Bcl-XL induces antitumor activity in uveal melanoma patient-derived xenografts. PLoS One 9:e80836 (2014). IHC-P ; Mouse . PubMed: 24454684
  • Xiao Q  et al. BEX1 promotes imatinib-induced apoptosis by binding to and antagonizing BCL-2. PLoS One 9:e91782 (2014). IP ; Human . PubMed: 24626299
  • Chou CP  et al. Ubiquitin-conjugating enzyme UBE2C is highly expressed in breast microcalcification lesions. PLoS One 9:e93934 (2014). WB ; Human . PubMed: 24699941
  • Bellas C  et al. Immunohistochemical and molecular characteristics with prognostic significance in diffuse large B-cell lymphoma. PLoS One 9:e98169 (2014). IHC-P ; Human . PubMed: 24887414
  • Cui SX  et al. 13F-1, a novel 5-fluorouracil prodrug containing an Asn-Gly-Arg (NO2) COOCH3 tripeptide, inhibits human colonic carcinoma growth by targeting Aminopeptidase N (APN/CD13). Eur J Pharmacol 734:50-9 (2014). PubMed: 24726845
  • Tao LJ  et al. Tetrandrine induces apoptosis and triggers a caspase cascade in U2-OS and MG-63 cells through the intrinsic and extrinsic pathways. Mol Med Rep 9:345-9 (2014). WB ; Human . PubMed: 24173687
  • Wang JF  et al. The molecular mechanisms of Tanshinone IIA on the apoptosis and arrest of human esophageal carcinoma cells. Biomed Res Int 2014:582730 (2014). WB ; Human . PubMed: 24829906
  • Nciri R  et al. Neuroprotective effects of chronic exposure of SH-SY5Y to low lithium concentration involve glycolysis stimulation, extracellular pyruvate accumulation and resistance to oxidative stress. Int J Neuropsychopharmacol 16:365-76 (2013). Human . PubMed: 22436355
  • Bertin-Ciftci J  et al. pRb/E2F-1-mediated caspase-dependent induction of Noxa amplifies the apoptotic effects of the Bcl-2/Bcl-xL inhibitor ABT-737. Cell Death Differ 20:755-64 (2013). Human . PubMed: 23429261
  • Ma BB  et al. Preclinical evaluation of the mTOR-PI3K inhibitor BEZ235 in nasopharyngeal cancer models. Cancer Lett N/A:N/A (2013). PubMed: 24041865
  • Han L  et al. Characterization of the Mechanism of Inhibin a-Subunit Gene in Mouse Anterior Pituitary Cells by RNA Interference. PLoS One 8:e74596 (2013). Mouse . PubMed: 24098340
  • Schuetz JM  et al. BCL2 mutations in diffuse large B-cell lymphoma. Leukemia 26:1383-90 (2012). IHC-P ; Human . PubMed: 22189900
  • Jung HJ  et al. Synergistic anticancer effects of arsenic trioxide with bortezomib in mantle cell lymphoma. Am J Hematol 87:1057-64 (2012). Human . PubMed: 22965904
  • Hoeller S  et al. Molecular and immunohistochemical characterization of B-cell lymphoma-2-negative follicular lymphomas. Hum Pathol 43:405-12 (2012). IHC-P ; Human . PubMed: 21855110
  • Thapa A  et al. Endoplasmic reticulum stress-associated cone photoreceptor degeneration in cyclic nucleotide-gated channel deficiency. J Biol Chem : (2012). Mouse . PubMed: 22493484
  • Jegalian AG  et al. Follicular lymphoma in situ: clinical implications and comparisons with partial involvement by follicular lymphoma. Blood 118:2976-84 (2011). IHC-P ; Human . PubMed: 21768298
  • Kawano Y  et al. Application of the histone deacetylase inhibitors for the treatment of endometriosis: histone modifications as pathogenesis and novel therapeutic target. Hum Reprod 26:2486-98 (2011). PubMed: 21715447
  • Tsuno A  et al. Fasudil inhibits the proliferation and contractility and induces cell cycle arrest and apoptosis of human endometriotic stromal cells: a promising agent for the treatment of endometriosis. J Clin Endocrinol Metab 96:E1944-52 (2011). Human . PubMed: 21917869
  • Oliver L  et al. Distinct roles of Bcl-2 and Bcl-Xl in the apoptosis of human bone marrow mesenchymal stem cells during differentiation. PLoS One 6:e19820 (2011). WB ; Human . PubMed: 21589877
  • Szyszko EA  et al. Salivary glands of primary Sjögren's syndrome patients express factors vital for plasma cell survival. Arthritis Res Ther 13:R2 (2011). IHC-P ; Human . PubMed: 21214903
  • Weisberg E  et al. Reversible resistance induced by FLT3 inhibition: a novel resistance mechanism in mutant FLT3-expressing cells. PLoS One 6:e25351 (2011). WB . PubMed: 21980431
  • Patel BP  et al. Caloric restriction shortens lifespan through an increase in lipid peroxidation, inflammation and apoptosis in the G93A mouse, an animal model of ALS. PLoS One 5:e9386 (2010). WB ; Mouse . PubMed: 20195368
  • Wang X  et al. miR-34a, a microRNA up-regulated in a double transgenic mouse model of Alzheimer's disease, inhibits bcl2 translation. Brain Res Bull 80:268-73 (2009). WB . PubMed: 19683563


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