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Read our guarantee »Overview
Product name
Anti-Bcl10 antibody [151]
See all Bcl10 products (17) ...
Description
Mouse monoclonal [151] to Bcl10
Tested applications
IHC-Pmore details
Cross reactivity
Reacts with
Human
Immunogen
Recombinant Human Bcl10
Epitope
The epitope recognized by ab93022 resides within amino acids 122-168 of the Human Bcl10 molecule.
Positive control
Tonsil
Properties
Form
Liquid
Storage instructions
Store at +4°C.
Storage buffer
Preservative: Sodium Azide
Constituents: PBS, BSA, pH 7.5
Concentration
Concentration information loading...
Purity
Protein G purified
Clonality
Monoclonal
Clone number
151
Isotype
IgG1
Research areas
Metabolism >> Pathways and Processes >> Metabolism processes >> Apoptosis
Cancer >> Signal transduction >> Nuclear signaling >> NFkB pathway
Cancer >> Invasion/microenvironment >> Apoptosis >> Bcl 2 family
Signal Transduction >> Signaling Pathway >> Nuclear Signaling >> NFkB Pathway
Cell Biology >> Apoptosis >> Intracellular >> Caspases etc >> CARD Family
Cell Biology >> Apoptosis >> Intracellular >> Bcl2 Family
Applications
Show applications key
Our Abpromise guarantee covers the use of ab93022 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IHC-P
Application notes
IHC-P: 1/25 - 1/100 in an ABC method. Antibody incubation period of 30 minutes at room temperature is recommended. Perform heat mediated antigen retrieval with 10mM citrate buffer, pH 6.0 before commencing with IHC staining protocol.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Function
Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1.
Tissue specificity
Ubiquitous.
Involvement in disease
Note=A chromosomal aberration involving BCL10 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(1;14)(p22;q32). Although the BCL10/IgH translocation leaves the coding region of BCL10 intact, frequent BCL10 mutations could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions.
Note=Defects in BCL10 are involved in various types of cancer.
Sequence similarities
Contains 1 CARD domain.
Post-translational
modifications
Phosphorylated. Phosphorylation results in dissociation from TRAF2 and binding to BIRC2/c-IAP2.
Cellular localization
Cytoplasm > perinuclear region. Membrane raft. Appears to have a perinuclear, compact and filamentous pattern of expression. Also found in the nucleus of several types of tumor cells. Colocalized with DPP4 in membrane rafts.
Target information above from: UniProt accessionO95999
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- AI132454 antibody
- B cell CLL/lymphoma 10 antibody
- B cell lymphoma/leukemia10 antibody
see all
Database links
- Entrez Gene: 8915 Human
- Omim: 603517 Human
- SwissProt: O95999 Human
- Unigene: 193516 Human
References for Anti-Bcl10 antibody [151] (ab93022)
This product has been referenced in:
- Shen L et al. Aberrant BCL10 nuclear expression in nasal NK/T-cell lymphoma. Blood 102:1553-4 (2003). IHC-P; Human.Read more (PubMed: 12900354) »
- Ye H et al. BCL10 expression in normal and neoplastic lymphoid tissue. Nuclear localization in MALT lymphoma. Am J Pathol 157:1147-54 (2000). WB, IHC-P; Human.Read more (PubMed: 11021819) »
See all 3 publications for this product
Publishing research using ab93022? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"