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Anti-Bcl10 antibody [DAA22] (ab49469)

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Overview

Product name

Anti-Bcl10 antibody [DAA22]
See all Bcl10 products (17) ...

Description

Mouse monoclonal [DAA22] to Bcl10

Tested applications

WBmore details

Cross reactivity

Reacts with

Human

Immunogen

Recombinant protein incorporating the majority of the coding sequence of the human Bcl10 molecule.

Positive control

Western Blotting: Tonsil.

Properties

Form

Liquid

Storage instructions

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: 15mM Sodium Azide
Constituents: Tissue culture supernatant

Purity

Tissue culture supernatant

Clonality

Monoclonal

Clone number

DAA22

Myeloma

P3-NS1/1-Ag4-1

Isotype

IgG1

Research areas

Metabolism >> Pathways and Processes >> Metabolism processes >> Apoptosis
Cancer >> Signal transduction >> Nuclear signaling >> NFkB pathway
Cancer >> Invasion/microenvironment >> Apoptosis >> Bcl 2 family
Signal Transduction >> Signaling Pathway >> Nuclear Signaling >> NFkB Pathway
Cell Biology >> Apoptosis >> Intracellular >> Caspases etc >> CARD Family
Cell Biology >> Apoptosis >> Intracellular >> Bcl2 Family

Applications

Show applications key

Our Abpromise guarantee covers the use of ab49469 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • WB

     

Application notes

WB: 1/25. Detects a band of approximately 32 kDa (predicted molecular weight: 31 kDa).
Note: Alkaline phosphatase method only is recommended.

Is unsuitable for IHC-P.

Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Target

Function

Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1.

Tissue specificity

Ubiquitous.

Involvement in disease

Note=A chromosomal aberration involving BCL10 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(1;14)(p22;q32). Although the BCL10/IgH translocation leaves the coding region of BCL10 intact, frequent BCL10 mutations could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions.
Note=Defects in BCL10 are involved in various types of cancer.

Sequence similarities

Contains 1 CARD domain.

Post-translational
modifications

Phosphorylated. Phosphorylation results in dissociation from TRAF2 and binding to BIRC2/c-IAP2.

Cellular localization

Cytoplasm > perinuclear region. Membrane raft. Appears to have a perinuclear, compact and filamentous pattern of expression. Also found in the nucleus of several types of tumor cells. Colocalized with DPP4 in membrane rafts.

Target information above from: UniProt accessionO95999 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • B cell lymphoma/leukemia10 antibody
  • AI132454 antibody
  • B cell CLL/lymphoma 10 antibody
  • B cell lymphoma/leukemia10 antibody
  • B-cell CLL/lymphoma 10 antibody
  • B-cell leukemia/lymphoma 10 antibody
  • B-cell lymphoma/leukemia 10 antibody
  • Bcl 10 antibody
  • Bcl-10 antibody
  • Bcl10 antibody
  • BCL10_HUMAN antibody
  • c E10 antibody
  • c-E10 antibody
  • C81403 antibody
  • CARD containing apoptotic signaling protein antibody
  • CARD containing molecule enhancing NF kappa B antibody
  • CARD containing molecule enhancing NF kB antibody
  • CARD containing molecule enhancing NFkB antibody
  • CARD containing proapoptotic protein antibody
  • CARD like apoptotic protein antibody
  • CARD-containing molecule enhancing NF-kappa-B antibody
  • CARD-like apoptotic protein antibody
  • CARMEN antibody
  • Caspase recruiting domain containing protein antibody
  • cCARMEN antibody
  • cE 10 antibody
  • cE10 antibody
  • CED 3/ICH 1 prodomain homologous E10 like regulator antibody
  • CED-3/ICH-1 prodomain homologous E10-like regulator antibody
  • CED3/ICH1 prodomain homologous E10 like regulator antibody
  • Cellular E10 antibody
  • Cellular homolog of vCARMEN antibody
  • Cellular-E10 antibody
  • CIPER antibody
  • CLAP antibody
  • hCLAP antibody
  • Mammalian CARD containing adapter molecule E10 antibody
  • Mammalian CARD-containing adapter molecule E10 antibody
  • mE 10 antibody
  • mE10 antibody
  • R-RCD1 antibody
see all

Database links

References for Anti-Bcl10 antibody [DAA22] (ab49469)

ab49469 has not yet been referenced specifically in any publications.

Publishing research using ab49469? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"