Bcl10 antibody [EP606Y] (ab33905)

Product Name 

Bcl10 antibody [EP606Y]

Product type 

Primary antibodies

Description 

Rabbit monoclonal [EP606Y] to Bcl10

Immunogen 

A synthetic peptide corresponding to residues in the C terminal of human Bcl10

Reacts with 

Hu

Does not react with 
(species key)

Ms, Rat

Tested applications 
(see key)

ICC/IF, IHC-P, IP, WB

Abreviews 

Customer reviews (see key)

Read about Abreviews

Application notes 
(see key)

Recommended dilutions
ICC: 1/100 - 1/250.
IF: Use at an assay dependent dilution.
IHC-P: 1/100 - 1/250.
IP: 1/50.
WB: 1/1000 - 1/5000. Detects a band of approximately 32 kDa (predicted molecular weight: 31 kDa).

Is unsuitable for FACS.


Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Positive control 
(see definition)

Raji cell lysate, Hela cell lysate and human hepatocellular carcinoma

Cellular localization 

Cytoplasmic. Appears to have a perinuclear, compact and filamentous pattern of expression. Also found in the nucleus of several types of tumor cells.

Research areas 

Cancer >> Signal transduction >> Nuclear signaling >> NFkB pathway
Cancer >> Invasion/microenvironment >> Apoptosis >> Bcl 2 family
Signal Transduction >> Signaling Pathway >> Nuclear Signaling >> NFkB Pathway
Cell Biology >> Apoptosis >> Intracellular >> Caspases etc >> CARD Family
Cell Biology >> Apoptosis >> Intracellular >> Bcl2 Family

Relevance 

Bcl10 / CIPER/ CLAP / mE10 is expressed in many human and murine tissues. It contains a CARD (caspase recruiting domain) domain and is involved in activation of caspase9 to induce apoptosis. It is a cellular homolog of equine herpesvirus 2 E-10. It is known to induce activation of JNK, p38 and NF kappaB. Mutations in Bcl10 are observed in many B and T cell lymphomas implicating its role in pathogenesis of human cancer.

Database links 

Raised in 

Rabbit

Clonality 

Monoclonal

Clone number 

EP606Y

Isotype 

IgG

Storage buffer 

Preservative: 0.01% Sodium Azide
Constituents: 40% Glycerol, 0.05% BSA, 0.15M Sodium chloride, 50mM Tris glycine. pH 7.4

Material safety datasheets (MSDS) for this product:
Glycerol MSDS
Sodium Azide MSDS

Form 

Liquid

Storage instructions 

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Notes 

Produced under U.S. Patent No. 5,675,063.

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