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- Proteins and Peptides
- Secondary antibodies
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Product name
Anti-Bcl10 antibody
See all Bcl10 products (17) ...
Description
Rabbit polyclonal to Bcl10
Tested applications
WB, ICC/IFmore details
Cross reactivity
Reacts with
Human
Immunogen
Synthetic peptide, corresponding to amino acids 5-19 of Human Bcl10.
Positive control
Raji whole cell lysate can be used as positive control and an approximately 31 kDa band can be detected.
Properties
Form
Liquid
Storage instructions
Store at +4°C.
Storage buffer
PBS with 0.02% sodium azide
Concentration
Concentration information loading...
Purity
IgG fraction
Clonality
Polyclonal
Isotype
IgG
Light chain type
unknown
Research areas
Metabolism >> Pathways and Processes >> Metabolism processes >> Apoptosis
Cancer >> Signal transduction >> Nuclear signaling >> NFkB pathway
Cancer >> Invasion/microenvironment >> Apoptosis >> Bcl 2 family
Signal Transduction >> Signaling Pathway >> Nuclear Signaling >> NFkB Pathway
Cell Biology >> Apoptosis >> Intracellular >> Caspases etc >> CARD Family
Cell Biology >> Apoptosis >> Intracellular >> Bcl2 Family
Applications
Show applications key
Our Abpromise guarantee covers the use of ab8398 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: 1/500. Detects a band of approximately 31 kDa.
ICC/IF: Use a concentration of 1 µg/ml.
Target
Function
Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1.
Tissue specificity
Ubiquitous.
Involvement in disease
Note=A chromosomal aberration involving BCL10 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(1;14)(p22;q32). Although the BCL10/IgH translocation leaves the coding region of BCL10 intact, frequent BCL10 mutations could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions.
Note=Defects in BCL10 are involved in various types of cancer.
Sequence similarities
Contains 1 CARD domain.
Post-translational
modifications
Phosphorylated. Phosphorylation results in dissociation from TRAF2 and binding to BIRC2/c-IAP2.
Cellular localization
Cytoplasm > perinuclear region. Membrane raft. Appears to have a perinuclear, compact and filamentous pattern of expression. Also found in the nucleus of several types of tumor cells. Colocalized with DPP4 in membrane rafts.
Target information above from: UniProt accessionO95999
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- AI132454 antibody
- B cell CLL/lymphoma 10 antibody
- B cell lymphoma/leukemia10 antibody
see all
Database links
- Entrez Gene: 8915 Human
- Omim: 603517 Human
- SwissProt: O95999 Human
- Unigene: 193516 Human
Anti-Bcl10 antibody images:
Western blot - Bcl10 antibody (ab8398)
All lanes : Anti-Bcl10 antibody (ab8398) at 1/500 dilution
Lane 1 : Raji whole cell lysate in absence of peptide
Lane 2 : Raji whole cell lysate in presence of peptide
Observed band size : 31 kDa (why is the actual band size different from the predicted?)
Immunocytochemistry/ Immunofluorescence - Bcl10 antibody (ab8398)
ab8398 at 1µg/ml staining Bcl10 in Raji cells by ICC/IF
References for Anti-Bcl10 antibody (ab8398)
ab8398 has not yet been referenced specifically in any publications.
Publishing research using ab8398? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"