Bcl10 antibody [ep605y] (ab40752)

Product Name 

Bcl10 antibody [ep605y]

Product type 

Primary antibodies

Description 

Rabbit monoclonal [ep605y] to Bcl10

Immunogen 

Synthetic peptide corresponding to residues near the N-terminal (Human)

Reacts with 

Hu

Does not react with 
(species key)

Ms, Rat

Tested applications 
(see key)

Flow Cyt, IHC-P, IP, WB

Abreviews 

Customer reviews (see key)

Read about Abreviews

Application notes 
(see key)

Recommended dilutions
Flow Cyt: 1/20.
IHC-P: 1/50.
IP: 1/30.
WB: 1/2000. Detects a band of approximately 32 kDa (predicted molecular weight: 31 kDa).


Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Cellular localization 

Cytoplasmic. Appears to have a perinuclear, compact and filamentous pattern of expression. Also found in the nucleus of several types of tumor cells.

Research areas 

Cancer >> Signal transduction >> Nuclear signaling >> NFkB pathway
Cancer >> Invasion/microenvironment >> Apoptosis >> Bcl 2 family
Signal Transduction >> Signaling Pathway >> Nuclear Signaling >> NFkB Pathway
Cell Biology >> Apoptosis >> Intracellular >> Caspases etc >> CARD Family
Cell Biology >> Apoptosis >> Intracellular >> Bcl2 Family

Relevance 

Bcl10 / CIPER/ CLAP / mE10 is expressed in many human and murine tissues. It contains a CARD (caspase recruiting domain) domain and is involved in activation of caspase9 to induce apoptosis. It is a cellular homolog of equine herpesvirus 2 E-10. It is known to induce activation of JNK, p38 and NF kappaB. Mutations in Bcl10 are observed in many B and T cell lymphomas implicating its role in pathogenesis of human cancer.

Database links 

Raised in 

Rabbit

Clonality 

Monoclonal

Clone number 

ep605y

Isotype 

IgG

Purity 

Whole Cell Lysate

Storage buffer 

Preservative: 0.01% Sodium Azide
Constituents: 40% Glycerol, 0.05% BSA, 0.15M Sodium chloride, 50mM Tris glycine, pH 7.4

Material safety datasheets (MSDS) for this product:
Glycerol MSDS
Sodium Azide MSDS

Form 

Liquid

Storage instructions 

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Notes 

Produced under U.S. Patent No. 5,675,063.

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