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Products:Immunology >> Adaptive Immunity >> B Cells >> Non-CD
Overview
Product name
Anti-Bcl3 antibody
See all Bcl3 products (5) ...
Description
Rabbit polyclonal to Bcl3
Tested applications
Cross reactivity
Reacts with
Human
Predicted to work with
Mouse, Rat
Immunogen
Synthetic peptides, corresponding to amino acids 2 - 13 and 107 - 120 of Human Bcl3.
Positive control
Tested with Jurkat cells.
Properties
Form
Liquid
Storage instructions
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 0.02% Sodium Azide
Constituents: PBS, 0.1mg/ml BSA
Concentration
Concentration information loading...
Purity
Protein G purified
Clonality
Polyclonal
Isotype
IgG
-
Western blot - Bcl3 antibody (ab13708)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab13708 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: Use a concentration of 0.5 - 1 µg/ml.Detects a band of approximately 45 kDa.
Target
Function
Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation.
Involvement in disease
Note=A chromosomal aberration involving BCL3 may be a cause of B-cell chronic lymphocytic leukemia (B-CLL). Translocation t(14;19)(q32;q13.1) with immunoglobulin gene regions.
Sequence similarities
Contains 7 ANK repeats.
Post-translational
modifications
Polyubiquitinated. Ubiquitination via 'Lys-63'-linked ubiquitin chains is required for nuclear accumulation. Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains. Deubiquitination by CYLD prevents nuclear accumulation.
Activated by phosphorylation.
Cellular localization
Nucleus. Cytoplasm. Cytoplasm > perinuclear region. Ubiquitination via 'Lys-63'-linked ubiquitin chains is required for nuclear accumulation.
Target information above from: UniProt accessionP20749
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- B cell CLL/lymphoma 3 antibody
- B cell leukemia/lymphoma 3 antibody
- B cell lymphoma 3 encoded protein antibody
see all
Database links
- Entrez Gene: 602 Human
- Entrez Gene: 12051 Mouse
- Entrez Gene: 680611 Rat
- Omim: 109560 Human
- SwissProt: P20749 Human
- SwissProt: Q3U300 Mouse
- SwissProt: Q9Z2F6 Mouse
- Unigene: 31210 Human
Anti-Bcl3 antibody images:
Western blot - Bcl3 antibody (ab13708)
Western blot analysis of Bcl-3 in Jurkat cells using ab13708 at 0.5 ug/ml.
References for Anti-Bcl3 antibody (ab13708)
ab13708 has not yet been referenced specifically in any publications.
Publishing research using ab13708? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"