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Read our guarantee »Products:Immunology >> Adaptive Immunity >> B Cells >> Non-CD
Anti-Bcl3 antibody
See all Bcl3 products (5) ...
Rabbit polyclonal to Bcl3
WB, IP, IHC-Frmore details
Reacts with
Mouse, Rat, Human
Synthetic peptide (Human) - mapping to the C terminus of Bcl 3.
Liquid
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Preservative: 0.02% Thimerosal (merthiolate)
Constituents: 50% Glycerol, 1.0% BSA, PBS, pH 7.2
Concentration information loading...
Protein G purified
Polyclonal
IgG
Western blot - Bcl3 antibody (ab27780)
(enlarge)
Our Abpromise guarantee covers the use of ab27780 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: Use a concentration of 1 - 4 µg/ml.Detects a band of approximately 60 kDa (predicted molecular weight: 47 kDa).
IP: Use a concentration of 5 - 10 µg/ml.
IHC-Fr: Use a concentration of 20 - 40 µg/ml.
Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation.
Note=A chromosomal aberration involving BCL3 may be a cause of B-cell chronic lymphocytic leukemia (B-CLL). Translocation t(14;19)(q32;q13.1) with immunoglobulin gene regions.
Contains 7 ANK repeats.
Polyubiquitinated. Ubiquitination via 'Lys-63'-linked ubiquitin chains is required for nuclear accumulation. Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains. Deubiquitination by CYLD prevents nuclear accumulation.
Activated by phosphorylation.
Nucleus. Cytoplasm. Cytoplasm > perinuclear region. Ubiquitination via 'Lys-63'-linked ubiquitin chains is required for nuclear accumulation.
Target information above from: UniProt accessionP20749
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Western blot - Bcl3 antibody (ab27780)

Anti-Bcl3 antibody (ab27780) at 2 µg/ml + Jurkat
Predicted band size : 47 kDa
ab27780 has not yet been referenced specifically in any publications.
Publishing research using ab27780? Please let us know so that we can cite the reference in this datasheet
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