CCL2, CCL7 and CCL8 inhibitor. Anti-inflammatory agent.
Biological descriptionCCL2, CCL7 and CCL8 inhibitor. Anti-inflammatory agent. Shows antiproliferative, antimetastatic and antitumor effects in vivo. Prevents neuroinflammation in vivo. Orally active.
Chemical name2-Methyl-2-[[1-(phenylmethyl)-1H-indazol-3-yl]methoxy]propanoic acid
Storage instructionsStore at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in ethanol to 25 mM and in DMSO to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Steiner JL et al. Effects of the MCP-1 synthesis inhibitor bindarit on tumorigenesis and inflammatory markers in the C3(1)/SV40Tag mouse model of breast cancer. Cytokine66:60-8 (2014).
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Ge S et al. The CCL2 synthesis inhibitor bindarit targets cells of the neurovascular unit, and suppresses experimental autoimmune encephalomyelitis. J Neuroinflammation9:171 (2012).
Read more (PubMed: 22788993) »
Zoja C et al. Bindarit retards renal disease and prolongs survival in murine lupus autoimmune disease. Kidney Int53:726-34 (1998).
Read more (PubMed: 9507220) »