Bindarit, CCL2, CCL7 and CCL8 inhibitor (ab143292)
Key features and details
- CCL2, CCL7 and CCL8 inhibitor. Anti-inflammatory agent.
- CAS Number: 130641-38-2
- Purity: > 99%
- Soluble in ethanol to 25 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Bindarit, CCL2, CCL7 and CCL8 inhibitor -
Description
CCL2, CCL7 and CCL8 inhibitor. Anti-inflammatory agent. -
Biological description
CCL2, CCL7 and CCL8 inhibitor. Anti-inflammatory agent. Shows antiproliferative, antimetastatic and antitumor effects in vivo. Prevents neuroinflammation in vivo. Orally active.
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Purity
> 99% -
CAS Number
130641-38-2 -
Chemical structure
Properties
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Chemical name
2-Methyl-2-[[1-(phenylmethyl)-1H-indazol-3-yl]methoxy]propanoic acid -
Molecular weight
324.38 -
Molecular formula
C19H20N2O3 -
PubChem identifier
71354 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in ethanol to 25 mM and in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
O=C(O)C(C)(C)OCc3nn(Cc1ccccc1)c2ccccc23 -
Source
Synthetic
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Research areas
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (2)
ab143292 has been referenced in 2 publications.
- Kripnerová M et al. Complex Interplay of Genes Underlies Invasiveness in Fibrosarcoma Progression Model. J Clin Med 10:N/A (2021). PubMed: 34070472
- Shen T et al. 15-Lipoxygenase and 15-hydroxyeicosatetraenoic acid regulate intravascular thrombosis in pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol 309:L449-62 (2015). PubMed: 26092993