Overview

  • Product nameBindarit
  • Description
    CCL2, CCL7 and CCL8 inhibitor. Anti-inflammatory agent.
  • Biological descriptionCCL2, CCL7 and CCL8 inhibitor. Anti-inflammatory agent. Shows antiproliferative, antimetastatic and antitumor effects in vivo. Prevents neuroinflammation in vivo. Orally active.
  • Purity> 99%

Properties

  • Chemical name2-Methyl-2-[[1-(phenylmethyl)-1H-indazol-3-yl]methoxy]propanoic acid
  • Molecular weight324.38
  • Chemical structureChemical Structure
  • Molecular formulaC19H20N2O3
  • CAS Number130641-38-2
  • PubChem identifier71354
  • Storage instructionsStore at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overviewSoluble in ethanol to 25 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILESO=C(O)C(C)(C)OCc3nn(Cc1ccccc1)c2ccccc23
  • Source

    Synthetic

  • Research areas

    Associated products

    References for Bindarit (ab143292)

    This product has been referenced in:
    • Steiner JL  et al. Effects of the MCP-1 synthesis inhibitor bindarit on tumorigenesis and inflammatory markers in the C3(1)/SV40Tag mouse model of breast cancer. Cytokine 66:60-8 (2014). Read more (PubMed: 24548426) »
    • Ge S  et al. The CCL2 synthesis inhibitor bindarit targets cells of the neurovascular unit, and suppresses experimental autoimmune encephalomyelitis. J Neuroinflammation 9:171 (2012). Read more (PubMed: 22788993) »
    • Zoja C  et al. Bindarit retards renal disease and prolongs survival in murine lupus autoimmune disease. Kidney Int 53:726-34 (1998). Read more (PubMed: 9507220) »

    See 0 Publications for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"