Overview

  • Product nameAnti-Bmi1 antibodySee all Bmi1 primary antibodies ...
  • Description
    Rabbit polyclonal to Bmi1
  • Tested applicationsIHC-P more details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    KLH conjugated synthetic peptide selected from the central region of Human BMI (NP_005171).

Properties

Applications

Our Abpromise guarantee covers the use of ab97729 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval in Sodium citrate pH6 buffer before commencing with IHC staining protocol.
  • Application notesIs unsuitable for WB.
  • Target

    • FunctionComponent of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.
    • Sequence similaritiesContains 1 RING-type zinc finger.
    • Post-translational
      modifications
      Monoubiquitinated (By similarity). May be polyubiquitinated; which does not lead to proteasomal degradation.
    • Cellular localizationNucleus. Cytoplasm.
    • Target information above from: UniProt accession P35226 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links
    • Alternative names
      • B lymphoma Mo MLV insertion region (mouse) antibody
      • B lymphoma Mo MLV insertion region 1 homolog antibody
      • Bmi 1 antibody
      • BMI1 antibody
      • BMI1 polycomb ring finger oncogene antibody
      • BMI1_HUMAN antibody
      • Flvi 2/bmi 1 antibody
      • FLVI2/BMI1 antibody
      • MGC12685 antibody
      • Murine leukemia viral (bmi 1) oncogene homolog antibody
      • Oncogene BMI 1 antibody
      • PCGF 4 antibody
      • PCGF4 antibody
      • Polycomb complex protein BMI 1 antibody
      • Polycomb complex protein BMI-1 antibody
      • Polycomb group protein Bmi1 antibody
      • Polycomb group ring finger 4 antibody
      • Polycomb group RING finger protein 4 antibody
      • RING finger protein 51 antibody
      • RNF 51 antibody
      • RNF51 antibody
      see all

    Anti-Bmi1 antibody images

    • (A) IHC staining for Bmi1 expression in primary Human neuroblastoma sample. A significant number of tumor cells show strong nuclear staining of Bmi1 (brown). (B) Immunohistochemical staining of SCG and neuroblastoma samples for Bmi1.

    References for Anti-Bmi1 antibody (ab97729)

    ab97729 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab97729.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"