Potent allosteric voltage-gated Na+ channel activator. Binds to site 5 on NaV channels causing excessive influx of Na+. Inactivates nerve fibers in vivo. Induces an inflammatory response. Orally active.
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Soluble in water and in ethanol
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
George J et al. Bidirectional influence of sodium channel activation on NMDA receptor-dependent cerebrocortical neuron structural plasticity. Proc Natl Acad Sci U S A109:19840-5 (2012).
Read more (PubMed: 23150561) »
Sas KM & Baatz JE Brevetoxin-2 induces an inflammatory response in an alveolar macrophage cell line. Int J Hyg Environ Health213:352-8 (2010).
Read more (PubMed: 20655277) »
Dravid SM et al. Brevetoxin activation of voltage-gated sodium channels regulates Ca dynamics and ERK1/2 phosphorylation in murine neocortical neurons. J Neurochem89:739-49 (2004).
Read more (PubMed: 15086530) »