Overview

  • Product name
    Brevetoxin2 (PbTx-2)
  • Description
    Potent allosteric voltage-gated Na+ channel activatior
  • Biological description
    Potent allosteric voltage-gated Na+ channel activator. Binds to site 5 on NaV channels causing excessive influx of Na+. Inactivates nerve fibers in vivo. Induces an inflammatory response. Orally active.
  • Purity
    > 95%

Properties

  • Molecular weight
    895.20
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C50H70O14
  • CAS Number
    79580-28-2
  • PubChem identifier
    57369879
  • Storage instructions
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in water and in ethanol
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    CC1CC2C(CC3(C(O2)CC4C(O3)C(=CC(=O)O4)C)C)OC5C1OC6CC7C(CC8C(O7)(CC=CC9C(O8)CC1C(O9)CC2C(O1)(C(CC(O2)CC(=C)C=O)O)C)C)(OC6(CC5)C)C
  • Source

    Synthetic

  • Research areas

    References for Brevetoxin2 (PbTx-2) (ab143469)

    This product has been referenced in:
    • George J  et al. Bidirectional influence of sodium channel activation on NMDA receptor-dependent cerebrocortical neuron structural plasticity. Proc Natl Acad Sci U S A 109:19840-5 (2012). Read more (PubMed: 23150561) »
    • Sas KM & Baatz JE Brevetoxin-2 induces an inflammatory response in an alveolar macrophage cell line. Int J Hyg Environ Health 213:352-8 (2010). Read more (PubMed: 20655277) »
    • Dravid SM  et al. Brevetoxin activation of voltage-gated sodium channels regulates Ca dynamics and ERK1/2 phosphorylation in murine neocortical neurons. J Neurochem 89:739-49 (2004). Read more (PubMed: 15086530) »

    See 0 Publications for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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