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AbcamBiochemicals (Asc-574)

Bromocriptine mesylate (ab120574)

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Overview

  • Product nameBromocriptine mesylate
  • Description
    Potent, selective D2-like dopamine receptor agonist
  • Biological descriptionPotent, selective D2-like dopamine receptor agonist (Ki values are ~8, ~5, ~290, ~440 and ~450 nM for D2, D3, D4, D1 and D5 receptors respectively). Inhibits the release of pituitary prolactin and stimulates motor activity in Parkinson's disease. Also reverses glutamate transporter 1 (GLT-1) activity, increasing glutamate levels.
  • Purity> 99%

    • Properties

  • Chemical name(5α)-2-Bromo-12'-hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)ergotaman-3',6',18-trione methanesulfonate
  • Molecular Weight750.70
  • Chemical structureChemical Structure
  • Molecular formulaC32H40BrN5O5.CH3SO3H
  • CAS Number22260-51-1
  • PubChem identifier31100
  • Storage instructionsStore at +4°C.
  • Solubility overviewSoluble in DMSO to 100 mM and in ethanol to 25 mM (with heating)
  • Handling

    Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

  • SMILESCS(=O)(=O)O.Brc3nc2cccc1C4=C[C@H](CN(C)[C@@H]4Cc3c12)C(=O)N[C@@]7(O[C@]6(O)N([C@@H](CC(C)C)C(=O)N5CCC[C@H]56)C7=O)C(C)C
  • Source

    Synthetic

  • Research Areas

    • References for Bromocriptine mesylate (ab120574)

    This product has been referenced in:
    • Shirasaki Y  et al. Bromocriptine, an ergot alkaloid, inhibits excitatory amino acid release mediated by glutamate transporter reversal. Eur J Pharmacol 643:48-57 (2010). Read more (PubMed: 20599932) »
    • Lindgren HS  et al. Differential involvement of D1 and D2 dopamine receptors in L-DOPA-induced angiogenic activity in a rat model of Parkinson's disease. Neuropsychopharmacology 34:2477-88 (2009). Read more (PubMed: 19606087) »
    • Valente D  et al. Metabolite involvement in bromocriptine-induced prolactin inhibition in rats. J Pharmacol Exp Ther 282:1418-24 (1997). Read more (PubMed: 9316855) »
    • Seeman P & Van Tol HH Dopamine receptor pharmacology. Trends Pharmacol Sci 15:264-70 (1994). Read more (PubMed: 7940991) »

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"