Anti-C1 Inactivator antibody - N-terminal (ab102663)

Overview

• Product nameAnti-C1 Inactivator antibody - N-terminalSee all C1 Inactivator primary antibodies ...
• Description
  Rabbit polyclonal to C1 Inactivator - N-terminal
• Tested applicationsWB more details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  Synthetic peptide corresponding to a region within N terminal amino acids 23 - 52 of Human C1 Inactivator (SwissProt ID: P05155), conjugated to KLH.

• Positive controlHL-60 cell lysate

Properties

• FormLiquid
• Storage instructionsStore at 4°C (up to 6 months). For long term storage store at -20°C
• Storage bufferPreservative: 0.09% Sodium Azide
  Constituents: PBS
• Concentration information loading...
• PurityAmmonium Sulphate Precipitation
• Purification notesPrepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Cardiovascular
  • Blood
  • Coagulation
  • Regulatory

  • Cardiovascular
  • Blood
  • Coagulation
  • Intrinsic

  • Cardiovascular
  • Blood
  • Fibrinolysis / Thrombolysis

  • Immunology
  • Innate Immunity
  • Complement
  • Classical Pathway

Applications

Target

• FunctionActivation of the C1 complex is under control of the C1-inhibitor. It forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Inhibits chymotrypsin and kallikrein.
• Involvement in diseaseDefects in SERPING1 are the cause of hereditary angioedema (HAE) [MIM:106100]; also called hereditary angioneurotic edema (HANE). HAE is an autosomal dominant disorder characterized by episodic local subcutaneous edema and submucosal edema involving the upper respiratory and gastrointestinal tracts. HAE due to C1 esterase inhibitor deficiency is comprised of two clinically indistinguishable forms. In HAE type 1, representing 85% of patients, serum levels of C1 esterase inhibitor are less than 35% of normal. In HAE type 2, the levels are normal or elevated, but the protein is non-functional.
• Sequence similaritiesBelongs to the serpin family.
• Post-translational
  modificationsHighly glycosylated (49%) with N- and O-glycosylation.
  Can be proteolytically cleaved by E.coli stcE.
• Cellular localizationSecreted.

Target information above from: UniProt accession P05155 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 710 Human
  • Omim: 606860 Human
  • SwissProt: P05155 Human
  • Unigene: 384598 Human

• Alternative names
  C1 esterase inhibitor antibodyC1 INH antibodyC1 inhibitor antibody

  C1-inhibiting factor antibodyC1IN antibodyC1Inh antibodyC1NH antibodyesterase inhibitor antibodyHAE1 antibodyIC1_HUMAN antibodyPlasma protease C1 inhibitor antibodySerine (or cysteine) proteinase inhibitor clade G member 1 antibodySerpin G1 antibodySERPING1 antibody

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Anti-C1 Inactivator antibody - N-terminal images

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  Western blot - C1 Inactivator antibody - N-terminal (ab102663)
  Anti-C1 Inactivator antibody - N-terminal (ab102663) at 1/50 dilution + HL-60 cell line lysates at 35 µg
  
  Predicted band size : 55 kDa