Anti-C1 Inactivator antibody - N-terminal (ab102663)
- Product nameAnti-C1 Inactivator antibody - N-terminalSee all C1 Inactivator primary antibodies ...
- DescriptionRabbit polyclonal to C1 Inactivator - N-terminal
- Tested applicationsWB more details
- Species reactivityReacts with: Human
Synthetic peptide corresponding to a region within N terminal amino acids 23 - 52 of Human C1 Inactivator (SwissProt ID: P05155), conjugated to KLH.
- Positive controlHL-60 cell lysate
- Storage instructionsStore at 4°C (up to 6 months). For long term storage store at -20°C
- Storage bufferPreservative: 0.09% Sodium Azide
- Concentration information loading...
- PurityAmmonium Sulphate Precipitation
- Purification notesPrepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
- Clonality Polyclonal
- Research Areas
Our Abpromise guarantee covers the use of ab102663 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||WB: 1/50 - 1/100. Predicted molecular weight: 55 kDa.|
- FunctionActivation of the C1 complex is under control of the C1-inhibitor. It forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Inhibits chymotrypsin and kallikrein.
- Involvement in diseaseDefects in SERPING1 are the cause of hereditary angioedema (HAE) [MIM:106100]; also called hereditary angioneurotic edema (HANE). HAE is an autosomal dominant disorder characterized by episodic local subcutaneous edema and submucosal edema involving the upper respiratory and gastrointestinal tracts. HAE due to C1 esterase inhibitor deficiency is comprised of two clinically indistinguishable forms. In HAE type 1, representing 85% of patients, serum levels of C1 esterase inhibitor are less than 35% of normal. In HAE type 2, the levels are normal or elevated, but the protein is non-functional.
- Sequence similaritiesBelongs to the serpin family.
modificationsHighly glycosylated (49%) with N- and O-glycosylation.
Can be proteolytically cleaved by E.coli stcE.
- Cellular localizationSecreted.
- C1 esterase inhibitor antibodyC1 INH antibodyC1 inhibitor antibody
- C1-inhibiting factor antibodyC1IN antibodyC1Inh antibodyC1NH antibodyesterase inhibitor antibodyHAE1 antibodyIC1_HUMAN antibodyPlasma protease C1 inhibitor antibodySerine (or cysteine) proteinase inhibitor clade G member 1 antibodySerpin G1 antibodySERPING1 antibody
Anti-C1 Inactivator antibody - N-terminal images
Anti-C1 Inactivator antibody - N-terminal (ab102663) at 1/50 dilution + HL-60 cell line lysates at 35 µg
Predicted band size : 55 kDa
References for Anti-C1 Inactivator antibody - N-terminal (ab102663)
ab102663 has not yet been referenced specifically in any publications.