C59, Wnt Antagonist, Wnt signaling pathway inhibitor (ab142216)
Key features and details
- Potent, cell-permeable Wnt signaling pathway inhibitor
- CAS Number: 1243243-89-1
- Purity: > 97%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
C59, Wnt Antagonist, Wnt signaling pathway inhibitor -
Description
Potent, cell-permeable Wnt signaling pathway inhibitor -
Biological description
Potent Wnt signaling pathway inhibitor. Inhibits porcupine (PORCN) required for Wnt palmitoylation, secretion, and biological activity. Inhibits Wnt-mediated transcription (IC50 = 74 pM) and cell proliferation. Active in vivo.
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Purity
> 97% -
CAS Number
1243243-89-1 -
Chemical structure
Properties
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Chemical name
2-[4-(2-Methylpyridin-4-yl)phenyl]-N-[4-(pyridin-3-yl)phenyl]acetamide -
Molecular weight
379.45 -
Molecular formula
C25H21N3O -
PubChem identifier
57519544 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1C2C(C2C3=C(N1CC4=CC=CC=C4)N=C5C=CC=CN5C3=O)C6=CC=CC=C6 -
Source
Synthetic
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Research areas
Images
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (17)
ab142216 has been referenced in 17 publications.
- Choi H et al. Inactivation of Sufu in cementoblasts accelerates external tooth root resorption. J Cell Physiol 238:447-458 (2023). PubMed: 36598878
- Wang Y et al. Loss of aquaporin 5 contributes to the corneal epithelial pathogenesis via Wnt/β-catenin pathway. FASEB J 37:e22776 (2023). PubMed: 36688817
- Gonnot F et al. SERCA2 phosphorylation at serine 663 is a key regulator of Ca2+ homeostasis in heart diseases. Nat Commun 14:3346 (2023). PubMed: 37291092
- Shinkawa T et al. Subtypes in pancreatic ductal adenocarcinoma based on niche factor dependency show distinct drug treatment responses. J Exp Clin Cancer Res 41:89 (2022). PubMed: 35272688
- Jobe NP et al. Reduced WNT5A signaling in melanoma cells favors an amoeboid mode of invasion. Mol Oncol 15:1835-1848 (2021). PubMed: 33969605