Anti-C9orf80 antibody (ab121623)

Overview

• Product nameAnti-C9orf80 antibody
• Description
  Rabbit polyclonal to C9orf80
• Tested applicationsICC/IF, WB, IHC-P more details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  antigen sequence: KEKRKLLMQN QSSTNHPGAS IALSRPSLNK DFRDHAEQQH IAAQQKAALQ HAHAHSSGYF ITQDSAFGNL, corresponding to amino acids 24-93 of Human C9orf80.

  Run BLAST with Run BLAST with
• Positive controlHuman adrenal gland tissue; Over-expression Lysate (Co-expressed with a C-terminal myc-DDK tag in mammalian HEK293T cells; Human cell line U 2 OS.

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Storage bufferpH: 7.20
  Preservative: 0.02% Sodium azide
  Constituents: 59% PBS, 40% Glycerol
• Concentration information loading...
• PurityImmunogen affinity purified
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Epigenetics and Nuclear Signaling
  • DNA / RNA
  • DNA Damage & Repair
  • DNA Damage Response
  • DNA Damage Recognition

  • Epigenetics and Nuclear Signaling
  • DNA / RNA
  • DNA Damage & Repair
  • DNA Damage Response
  • Other

  • Epigenetics and Nuclear Signaling
  • DNA / RNA
  • DNA Damage & Repair
  • Nucl. Excision Repair

  • Epigenetics and Nuclear Signaling
  • DNA / RNA
  • DNA Synthesis
  • Translesion Synthesis

  • Epigenetics and Nuclear Signaling
  • DNA / RNA
  • DNA Damage & Repair
  • Base Excision Repair

  • Epigenetics and Nuclear Signaling
  • DNA / RNA
  • DNA Damage & Repair
  • Mismatch Repair

  • Epigenetics and Nuclear Signaling
  • DNA / RNA
  • DNA Damage & Repair
  • Non Homol. End Joining

Applications

Target

• FunctionComponent of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.
• Sequence similaritiesBelongs to the SOSS-C family.
• Cellular localizationNucleus. Localizes to nuclear foci following DNA damage.

Target information above from: UniProt accession Q9NRY2 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 58493 Human
  • Entrez Gene: 58493 Human
  • Omim: 613273 Human
  • SwissProt: Q9NRY2 Human
  • SwissProt: Q9NRY2 Human
  • Unigene: 658575 Human

• Alternative names
  Chromosome 9 open reading frame 80 antibodyhSSBIP1 antibodyMISE antibody

  RP11-276E15.2 antibodySensor of single-strand DNA complex subunit C antibodySensor of ssDNA subunit C antibodySingle-stranded DNA-binding protein-interacting protein 1 antibodySOSS C antibodySOSS complex subunit C antibodySOSS-C antibodySOSSC antibodySOSSC_HUMAN antibodySSB-interacting protein 1 antibodySsbip1 antibody

  see all

Anti-C9orf80 antibody images

• 

  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C9orf80 antibody (ab121623)
  ab121623 at 1/40 dilution staining C9orf80 in Paraffin Embedded Human adrenal gland tissue by Immunohistochemistry.
  Note: strong nuclear positivity in cortical cells.
• 

  Western blot - Anti-C9orf80 antibody (ab121623)
  All lanes : Anti-C9orf80 antibody (ab121623) at 1/250 dilution
  
  Lane 1 : Negative control (vector only transfected HEK293T lysate)
  Lane 2 : Over-expression Lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells
  
  developed using the ECL technique
• 

  Immunocytochemistry/ Immunofluorescence - Anti-C9orf80 antibody (ab121623)
  ab121623 at 4 µg/ml staining C9orf80 in PFA/Triton X-100 fixed/permeabilized U 2 OS cells by Immunofluorescence (green).
  Note: positivity in nuclei but not nucleoli.