You have changed your country from  to  . Please be aware that this will change the currency in the purchasing process.

Overview

  • Product nameAnti-CABP antibody - Azide freeSee all CABP primary antibodies ...
  • Description
    Chicken polyclonal to CABP - Azide free
  • Tested applicationsWB more details
  • Species reactivity
    Reacts with: Rat, Human
  • Immunogen

    Synthetic peptide, corresponding to amino acids 15-227 of Human CABP

Properties

Applications

Our Abpromise guarantee covers the use of ab37748 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB WB: 1/500. Predicted molecular weight: 26 kDa.

Target

  • FunctionModulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors (ITPRs). Inhibits agonist-induced intracellular calcium signaling. Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels. Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but resulting in an opposit effects on channel function. Suppresses the calcium-dependent inactivation of CACNA1D (By similarity). Inhibits TRPC5 channels. Prevents NMDA receptor-induced cellular degeneration.
  • Tissue specificityRetina and brain. Somatodendritic compartment of neurons. Calbrain was found exclusively in brain where it is abundant in the hippocampus, habenular area in the epithalamus and in the cerebellum.
  • Sequence similaritiesContains 4 EF-hand domains.
  • DomainEF-1 binds magnesium constitutively under physiological conditions, EF-3 and EF-4 bind calcium cooperatively and EF-2 binds neither calcium nor magnesium.
  • Post-translational
    modifications    Phosphorylated. The phosphorylation regulates the activity.
  • Cellular localizationCytoplasm > cell cortex. Cell membrane. S-CaBP1 is localized at or near the plasma membrane; Cytoplasm > cytoskeleton. Cytoplasm > perinuclear region. Cell membrane. Golgi apparatus. Cell junction > synapse > postsynaptic cell membrane > postsynaptic density. L-CaBP1 is associated most likely with the cytoskeletal structures, whereas S-CaBP1 is localized at or near the plasma membrane and Cytoplasm > cytoskeleton. L-CaBP1 is associated most likely with the cytoskeletal structures.

    • Target information above from: UniProt accession Q9NZU7 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
    • Alternative names
        CABP 1 antibodyCaBP1 antibodyCABP1_HUMAN antibody
        Calbrain antibodyCalcium binding protein 1 antibodyCalcium binding protein 5 antibodyCalcium-binding protein 1 antibodyCaldendrin antibodyHCALB BR antibodyHCALB_BR antibody
      see all

    References for Anti-CABP antibody - Azide free (ab37748)

    ab37748 has not yet been referenced specifically in any publications.

    Publishing research using ab37748 ? Please let us know so that we can cite the reference in this datasheet

    Product Wall

    Submit an Abreview for ab37748 Submit a Question for ab37748

    There are currently no Abreviews or Questions for ab37748.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"