CACNA1G + CACNA1H antibody (ab81099)

Product Name 

CACNA1G + CACNA1H antibody

Product type 

Primary antibodies

Description 

Rabbit polyclonal to CACNA1G + CACNA1H

Immunogen 

Synthetic peptide from a cytoplasmic domain of Human CACNA1H + CACNA1G, conjugated to an immunogenic carrier protein

Reacts with 
(species key)

Hu, Ms, Rat

Tested applications 
(see key)

IHC-Fr, IHC-P, WB

Abreviews 

Customer reviews (see key)

Read about Abreviews

Application notes 
(see key)

Recommended dilutions
IHC-P: Use at a concentration of 10 - 50 µg/ml. Antigen retrieval is recommended.
IHC-Fr: Use at a concentration of 10 - 50 µg/ml.
WB: Use at a concentration of 10 - 50 µg/ml. Predicted molecular weight: 259 and 262 kDa (isoforms 1).


Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Cellular localization 

Cell Membrane

Research areas 

Signal Transduction >> Signaling Pathway >> Calcium Signaling >> Calcium Channels

Relevance 

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by mibefradil. A particularity of this type of channels is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.
There are 2 isoforms of CACNA1H and 14 isoforms if CACNA1G, produced by alternative splicing.

Database links 

Raised in 

Rabbit

Clonality 

Polyclonal

Isotype 

IgG

Purity 

IgG fraction

Storage buffer 

Preservative: None
Constituents: PBS

Form 

Liquid

Concentration 

1.000 mg/ml

Storage instructions 

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C (add glycerol to a final volume of 40% for extra stability). Avoid repeated freeze / thaw cycles.

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