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Products:Signal Transduction >> Signaling Pathway >> Calcium Signaling >> Calcium Channels
Overview
Product name
Anti-CACNA1G + CACNA1H antibody
See all CACNA1G + CACNA1H products (2) ...
Description
Rabbit polyclonal to CACNA1G + CACNA1H
Tested applications
WB, IHC-P, IHC-Frmore details
Cross reactivity
Reacts with
Mouse, Rat, Human
Immunogen
Synthetic peptide from a cytoplasmic domain of Human CACNA1H + CACNA1G, conjugated to an immunogenic carrier protein
Properties
Form
Liquid
Storage instructions
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C (add glycerol to a final volume of 40% for extra stability). Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
Constituents: PBS
Concentration
Concentration information loading...
Purity
IgG fraction
Clonality
Polyclonal
Isotype
IgG
Research areas
Signal Transduction >> Signaling Pathway >> Calcium Signaling >> Calcium Channels
Applications
Show applications key
Our Abpromise guarantee covers the use of ab81099 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB
IHC-P
IHC-Fr
Application notes
IHC-P: Use at a concentration of 10 - 50 µg/ml. Antigen retrieval is recommended.
IHC-Fr: Use at a concentration of 10 - 50 µg/ml.
WB: Use at a concentration of 10 - 50 µg/ml. Predicted molecular weight: 259 and 262 kDa (isoforms 1).
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Relevance
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by mibefradil. A particularity of this type of channels is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. There are 2 isoforms of CACNA1H and 14 isoforms if CACNA1G, produced by alternative splicing.
Cellular localization
Cell Membrane
Alternative names
- Cav3.1c antibody
- Low voltage activated calcium channel alpha1 3.2 subunit antibody
- NBR13 antibody
see all
Database links
- Entrez Gene: 8912 Human
- Entrez Gene: 8913 Human
- Entrez Gene: 12291 Mouse
- Entrez Gene: 58226 Mouse
- Entrez Gene: 114862 Rat
- Entrez Gene: 29717 Rat
- Omim: 604065 Human
- Omim: 607904 Human
see all
References for Anti-CACNA1G + CACNA1H antibody (ab81099)
ab81099 has not yet been referenced specifically in any publications.
Publishing research using ab81099? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"