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Product name
Anti-CAMKIV antibody
See all CAMKIV products (13) ...
Description
Rabbit polyclonal to CAMKIV
Tested applications
ELISA, WBmore details
Cross reactivity
Reacts with
Mouse, Human
Immunogen
Synthetic peptide: ELEEGLAEEKLKTVEE conjugated to KLH, corresponding to C terminal amino acids 431-446 of Human CAMKIV
ELEEGLAEEKLKTVEE
Positive control
Ramos cell lysate, mouse cerebellum tissue lysate.
Properties
Form
Liquid
Storage instructions
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 0.09% Sodium Azide
Constituents: PBS
Concentration
Concentration information loading...
Purity
Protein G purified
Clonality
Polyclonal
Isotype
IgG
-
Western blot - CAMKIV antibody (ab37997)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab37997 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ELISA
ELISA: 1/1000.ELISA: 1/1000.
WB: 1/100 - 1/500. Detects a band of approximately 52 kDa (predicted molecular weight: 52 kDa).
Target
Function
Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. May be involved in transcriptional regulation. May be involved in regulation of microtubule dynamics. In vitro, phosphorylates CREB1, CREBBP, PRM2, MEF2A, MEF2D and STMN1/OP18. May be involved in spermatogenesis. May play a role in the consolidation/retention of hippocampus-dependent long-term memory.
Tissue specificity
Expressed in epithelial ovarian cancer tissue.
Sequence similarities
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
Contains 1 protein kinase domain.
Post-translational
modifications
Autophosphorylated and phosphorylated by CAMKK1 and CAMKK2 (By similarity). Dephosphorylated by serine/threonine protein phosphatase 2A, probably on Thr-200.
Cellular localization
Cytoplasm. Nucleus. Substantial localization in certain neuronal nuclei. In spermatids associated with chromatin and nuclear matrix.
Target information above from: UniProt accessionQ16566
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- Brain Ca(2+) calmodulin dependent protein kinase type 4 antibody
- Brain Ca(2+) calmodulin dependent protein kinase type IV antibody
- Calcium / calmodulin dependent protein kinase type 4 catalytic chain antibody
see all
Database links
- Entrez Gene: 814 Human
- Entrez Gene: 12326 Mouse
- Omim: 114080 Human
- SwissProt: Q16566 Human
- SwissProt: P08414 Mouse
- Unigene: 591269 Human
- Unigene: 222329 Mouse
Anti-CAMKIV antibody images:
Western blot - CAMKIV antibody (ab37997)
All lanes : Anti-CAMKIV antibody (ab37997) at 1/100 dilution
Lane 1 : Ramos cell lysate
Lane 2 : Mouse cerebellum tissue lysate
Secondary
HRP-anti-rabbit
Predicted band size : 52 kDa
Observed band size : 52 kDa
References for Anti-CAMKIV antibody (ab37997)
ab37997 has not yet been referenced specifically in any publications.
Publishing research using ab37997? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"