Anti-CAMLG/CAML antibody (ab67714)
Key features and details
- Mouse polyclonal to CAMLG/CAML
- Suitable for: WB
- Reacts with: Rat, Human
- Isotype: IgG
Overview
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Product name
Anti-CAMLG/CAML antibody
See all CAMLG/CAML primary antibodies -
Description
Mouse polyclonal to CAMLG/CAML -
Host species
Mouse -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Rat, Human -
Immunogen
Recombinant full length protein within Human CAMLG/CAML aa 1-300. The exact immunogen sequence used to generate this antibody is proprietary information. If additional detail on the immunogen is needed to determine the suitability of the antibody for your needs, please contact our Scientific Support team to discuss your requirements.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
pH: 7.40
Constituent: 100% PBS -
Concentration information loading...
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Purity
Protein G purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab67714 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/500 - 1/1000. Predicted molecular weight: 33 kDa.
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Notes |
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WB
1/500 - 1/1000. Predicted molecular weight: 33 kDa. |
Target
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Relevance
The immunosuppressant drug cyclosporin A blocks a calcium dependent signal from the T cell receptor (TCR) that normally leads to T cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin. [Entrez Gene] -
Cellular localization
Membrane; Multi pass membrane protein. -
Database links
- Entrez Gene: 819 Human
- Entrez Gene: 81715 Rat
- Omim: 601118 Human
- SwissProt: P49069 Human
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Alternative names
- calcium modulating cyclophilin ligand antibody
- calcium modulating ligand antibody
- Calcium signal modulating cyclophilin ligand antibody
see all
Images
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Anti-CAMLG/CAML antibody (ab67714) at 1/500 dilution + rat brain at 25 µg
Secondary
Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution
Predicted band size: 33 kDa
Observed band size: 33 kDa -
All lanes : Anti-CAMLG/CAML antibody (ab67714) at 1/500 dilution
Lane 1 : CAMLG/CAML transfected 293T cell lysate
Lane 2 : non transfected 293T cell lysate
Lysates/proteins at 25 µg per lane.
Secondary
All lanes : Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution
Predicted band size: 33 kDa
Observed band size: 33 kDa
Datasheets and documents
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Datasheet download
References (1)
ab67714 has been referenced in 1 publication.
- He B et al. The transmembrane activator TACI triggers immunoglobulin class switching by activating B cells through the adaptor MyD88. Nat Immunol 11:836-45 (2010). WB, ICC/IF ; Human . PubMed: 20676093