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Product Name
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CARD10 peptide
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Product type
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Proteins and Peptides
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Peptide
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Synthetic peptide (Human)
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Tested applications
(see key)
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BL, WB
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Application notes
(see key)
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Recommended dilutions
BL: Use at an assay dependent dilution.
WB: Use at an assay dependent dilution. Predicted molecular weight: 116 kDa.
This peptide usually blocks ab36839 activity completely in Western blot: incubate this peptide with equal volume of antibody for 30 min at 37°C.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Research areas
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Cell Biology >> Apoptosis >> Intracellular >> Caspases etc >> CARD Family
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Relevance
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Apoptosis is related to many diseases and development. Cell death signals are transduced by death domain (DD), death effector domain (DED), and caspase recruitment domain (CARD) containing molecules. CARD containing proteins include some caspases, Apaf-1, CARD4, IAPs, RICK, ARC, RAIDD, Bcl 10, and ASC. A novel CARD containing protein was recently identified and designated CARD10. This protein belongs to the membrane associated guanylate kinase-like (MAGUK) family of proteins that can function as molecular scaffolds that assist assembly of signal transduction molecules. CARD 10 interacts with Bcl-10, a Bcl protein that promotes apoptosis, caspase-9 maturation and activation of NF-kB. CARD 10 and the related protein CARMA1 also associate with NEMO, the regulatory subunit of the IkK complex, demonstrating its importance in the regulation of NF-kB transcription factor activation.
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Storage buffer
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Preservative: 0.02% Sodium Azide
Constituents: PBS, 0.1% bovine serum albumin, pH 7.2 Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS
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Form
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Liquid
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Concentration
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0.200 mg/ml
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Storage instructions
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this CARD10 peptide is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to CARD10
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CARD10 peptide - more information
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Customer reviews (feedback) regarding CARD10 peptide |
Customer FAQs regarding CARD10 peptide |
Protocols for CARD10 peptide |
Price and availability of products related to CARD10 peptide |
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CARD10 peptide - related products:
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CARD10 peptide - other tools:
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Contact Abcam with a Technical Enquiry about CARD10 peptide |
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All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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