Anti-CCKBR antibody (ab14439)

Overview

• Product nameAnti-CCKBR antibodySee all CCKBR primary antibodies ...
• Description
  Rabbit polyclonal to CCKBR
• Tested applicationsWB more details
• Species reactivity
  Reacts with: Human
  Predicted to work with: Mouse, Rat, Rabbit, Cow
• Immunogen

  Poly Lysin conjugated synthetic peptide: VYTVVQPVGPRVLQ, corresponding to amino acids 191-204 of Human CCKBR.

  Run BLAST with Run BLAST with

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Storage bufferPreservative: None
  Constituents: Whole Serum
• PurityWhole antiserum
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Metabolism
  • Types of disease
  • Obesity

  • Neuroscience
  • Endocrine system
  • Hypothalamic pituitary adrenal axis

  • Neuroscience
  • Neurotransmission
  • Receptors / Channels
  • GPCR
  • More GPCR

Applications

Target

• FunctionReceptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
  Isoform 2 is constitutively activated and may regulate cancer cell proliferation via a gastrin-independent mechanism.
• Tissue specificityIsoform 1 is expressed in brain, pancreas, stomach, the colon cancer cell line LoVo and the T-lymphoblastoma Jurkat, but not in heart, placenta, liver, lung, skeletal muscle, kidney or the stomach cancer cell line AGS. Expressed at high levels in the small cell lung cancer cell line NCI-H510, at lower levels in NCI-H345, NCI-H69 and GLC28 cell lines, not expressed in GLC19 cell line. Within the stomach, expressed at high levels in the mucosa of the gastric fundus and at low levels in the antrum and duodenum. Isoform 2 is present in pancreatic cancer cells and colorectal cancer cells, but not in normal pancreas or colonic mucosa. Isoform 3 is expressed in brain, pancreas, stomach, the stomach cancer cell line AGS and the colon cancer cell line LoVo.
• Sequence similaritiesBelongs to the G-protein coupled receptor 1 family.
• Cellular localizationCell membrane.

Target information above from: UniProt accession P32239 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 281665 Cow
  • Entrez Gene: 887 Human
  • Entrez Gene: 12426 Mouse
  • Entrez Gene: 25706 Rat
  • Omim: 118445 Human
  • SwissProt: P79266 Cow
  • SwissProt: P32239 Human
  • SwissProt: P56481 Mouse

  • SwissProt: P46627 Rabbit
  • SwissProt: P30553 Rat
  • Unigene: 203 Human
  • Unigene: 44513 Mouse
  • Unigene: 90997 Rat

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• Alternative names
  CCK B antibodyCCK B receptor antibodyCCK BR antibody

  CCK-B receptor antibodyCCK-BR antibodyCCK2 R antibodyCCK2 receptor antibodyCCK2-R antibodyCCKB antibodyCCKB receptor antibodyCCKBR antibodyCCKR Type B antibodyCCKRB antibodyCholecystokinin 2 receptor antibodyCholecystokinin B receptor antibodyCholecystokinin-2 receptor antibodyCholecystokinin2 receptor antibodyCholecystokininB receptor antibodyGASR antibodyGASR_HUMAN antibodyGastrin receptor antibodyGastrin/cholecystokinin type B receptor antibodyGastrin\cholecystokinin brain receptor antibody

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