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Overview

  • Product nameAnti-CCNL1 antibodySee all CCNL1 primary antibodies ...
  • Description
    Rabbit polyclonal to CCNL1
  • Tested applicationsWB, ELISA more details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow
  • Immunogen

    A region within a synthetic peptide: TGGILIGDRL YSEVSLTIDH SLIPEERLSP TPSMQDGLDL PSETDLRILG, corresponding to N terminal amino acids 37-86 of Human CCNL1

    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
  • Positive controlHepG2 cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab26253 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB WB: Use a concentration of 2.5 µg/ml. Detects a band of approximately 57 kDa (predicted molecular weight: 60 kDa). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
ELISA ELISA: 1/62500.

Target

  • FunctionTranscriptional regulator which participates in regulating the pre-mRNA splicing process. Seems to be involved in the regulation of RNA polymerase II (pol II). Functions in association with cyclin-dependent kinases (CDKs) and has a role in the second step of splicing. May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC). Inhibited by the CDK-specific inhibitor p21.
  • Tissue specificityUbiquitous with higher level in thymus. Overexpression in primary tumors of head and neck squamous cell carcinomas (HNSCC).
  • Sequence similaritiesBelongs to the cyclin family. Cyclin L subfamily.
  • DomainContains a RS region (arginine-serine dipeptide repeat) within the C-terminal domain which is the hallmark of the SR family of splicing factors. This region probably plays a role in protein-protein interactions.
  • Cellular localizationNucleus speckle. More specifically found in nuclear intrachromatin granules clusters (IGC), also called nuclear speckles, which are storage compartments for nuclear proteins involved in mRNA processing.

    • Target information above from: UniProt accession Q9UK58 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
    see all
  • Alternative names
      Ania 6a antibodyBM 001 antibodyCCNL 1 antibody
      CCNL1 antibodyCCNL1_HUMAN antibodyCyclin L ania 6a antibodyCyclin L antibodyCyclin L gamma antibodyCyclin L1 antibodyCyclin-L antibodyCyclin-L1 antibody
    see all

Anti-CCNL1 antibody images

References for Anti-CCNL1 antibody (ab26253)

ab26253 has not yet been referenced specifically in any publications.

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