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Products:Immunology >> Innate Immunity >> Macrophage / Inflamm.
Overview
Product name
Anti-CCR2 antibody
See all CCR2 products (6) ...
Description
Goat polyclonal to CCR2
Specificity
Peptide sequence is < 50 % identical to other human chemokine receptors in this region.
Tested applications
ELISA, ICC, IHC-P, WBmore details
Cross reactivity
Reacts with
Human
Immunogen
Synthetic peptide: C-GEEVTTFFDYDYGAPCHKFDVKQ, corresponding to N terminal amino acids 17-39 of Human CCR2.
C-GEEVTTFF DYDYGAPCHK FDVKQ
Positive control
Human peripheral blood cells or section of spleen.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 0.1% Sodium Azide
Constituents: PBS, 1mg/ml BSA
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Cardiovascular >> Atherosclerosis >> Vascular Inflammation >> Leukocyte recruitment >> Chemokines
Cancer >> Signal transduction >> G protein signaling >> GPCR
Signal Transduction >> Signaling Pathway >> G Protein Signaling >> GPCR
Signal Transduction >> Signaling Pathway >> Nuclear Signaling >> STATs
Microbiology >> Interspecies Interaction >> Host Virus Interaction
Immunology >> Innate Immunity >> Chemokines >> Beta Chemokine Rec. (CCR)
Immunology >> Innate Immunity >> Macrophage / Inflamm.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - CCR2 antibody (ab1668)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab1668 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ELISA
ELISA: 1/60000ELISA: 1/60000
ICC
ICC: 1/400ICC: 1/400
IHC-P: 1/200Antigen retrieval is not essential but may optimise staining.
WB
WB: 1/1000WB: 1/1000
Target
Relevance
CCR2, or C C chemokine receptor type 2, is a receptor for several monocyte chemo attractant proteins (MCP1, MCP3, MCP4) which specifically mediate monocyte chemotaxis. CCR2 transduces such signals by increasing the intracellular level of calcium ions. For example, MCP1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. CCR2 is also an alternative coreceptor with CD4 for HIV1 infection. CCR2 has two isoforms and has been reported to be expressed in a wide variety of tissues, including blood, brain, heart, kidney, liver, lung, ovary, pancreas, spinal cord, spleen and thymus.
Cellular localization
Cell membrane; Multi-pass membrane protein
Alternative names
- C C chemokine receptor type 2 antibody
- C C CKR 2 antibody
- CC chemokine receptor type 2 antibody
see all
Database links
- Entrez Gene: 1231 Human
- Omim: 601267 Human
- SwissProt: P41597 Human
Anti-CCR2 antibody images:
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - CCR2 antibody (ab1668)
ab1668, at a dilution of 1/200, staining CCR2 in human spleen section by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections).
References for Anti-CCR2 antibody (ab1668)
This product has been referenced in:
- Song CHet al. Identification of chemoattractive factors involved in the migration of bone marrow-derived mesenchymal stem cells to brain lesions caused by prions. J Virol 85:11069-78 (2011).Read more (PubMed: 21813601) »
- Levina Vet al. Role of eotaxin-1 signaling in ovarian cancer. Clin Cancer Res 15:2647-56 (2009). IHC-P; Human.Read more (PubMed: 19351767) »
See all 6 publications for this product
Publishing research using ab1668? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"