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- Secondary antibodies
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Product name
Anti-CCR3 antibody
See all CCR3 products (8) ...
Description
Rabbit polyclonal to CCR3
Specificity
Detects CCR3.
Tested applications
Cross reactivity
Reacts with
Mouse, Rat, Human
Immunogen
Synthetic peptide raised against a 14 amino acid peptide from near the amino terminus of human CCR3.
Positive control
Human spleen cell lysate.
Properties
Form
Liquid
Storage instructions
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 0.02% Sodium Azide
Constituents: PBS, pH 8
Concentration
Concentration information loading...
Purity
Ion Exchange Chromatography
Purification notes
Purified by DEAE column chromatography.
Clonality
Polyclonal
Isotype
IgG
Research areas
Immunology >> Immune System Diseases >> Antiviral Signaling >> HIV-related
Signal Transduction >> Signaling Pathway >> G Protein Signaling >> GPCR
Immunology >> Innate Immunity >> Chemokines >> Beta Chemokine Rec. (CCR)
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Western blot - CCR3 antibody (ab36829)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab36829 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: Use a concentration of 1 - 2 µg/ml. Detects a band of approximately 55 kDa (predicted molecular weight: 43 kDa).
Target
Function
Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.
Tissue specificity
In eosinophils as well as trace amounts in neutrophils and monocytes.
Sequence similarities
Belongs to the G-protein coupled receptor 1 family.
Cellular localization
Cell membrane.
Target information above from: UniProt accessionP51677
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- B chemokine receptor antibody
- C C chemokine receptor type 3 antibody
- C C CKR 3 antibody
see all
Database links
- Entrez Gene: 1232 Human
- Entrez Gene: 12771 Mouse
- Entrez Gene: 117027 Rat
- Omim: 601268 Human
- SwissProt: P51677 Human
- SwissProt: P51678 Mouse
- SwissProt: O54814 Rat
- Unigene: 506190 Human
see all
Anti-CCR3 antibody images:
Western blot - CCR3 antibody (ab36829)
Lane 1 : Anti-CCR3 antibody (ab36829) at 1 µg/ml
Lanes 2 - 3 : Anti-CCR3 antibody (ab36829) at 2 µg/ml
Lane 1 : Human spleen tissue lysates
Lane 2 : Human spleen tissue lysates
Lane 3 : Human spleen tissue lysates with blocking peptide
Lysates/proteins at 15 µg per lane.
Predicted band size : 43 kDa
Observed band size : 55 kDa (why is the actual band size different from the predicted?)
References for Anti-CCR3 antibody (ab36829)
ab36829 has not yet been referenced specifically in any publications.
Publishing research using ab36829? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"