CCR5 antibody (ab1673)

Product Name 

CCR5 antibody

Product type 

Primary antibodies

Description 

Goat polyclonal to CCR5

Immunogen 

Synthetic peptide: YQVSSPIYDINYYTSEPCQKINVKQIAA, corresponding to N terminal amino acids 3-30 of Human CCR5.
BLAST 'YQVSSPIYDINYYTSEPCQKINVKQIAA' with or

Reacts with 
(species key)

Hu, Mcq

Specificity 

This antibody binds to CCR 5 receptors on human peripheral blood leukocytes as determined by immunocytochemistry.

Tested applications 
(see key)

ELISA, ICC, IHC-Fr, IHC-P, WB

Abreviews 

Customer reviews (see key)

Read about Abreviews

Application notes 
(see key)

Recommended dilutions
ELISA: 1/50000. Tested in Peptide ELISA only, not tested and characterized for endogenous samples in ELISA.
ICC: 1/300.
IHC-P: 1/300 with biotinylated secondary and streptavidin-HRP.
IHC-Fr: Use at an assay dependent dilution.
WB: 1/1000.


Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Positive control 
(see definition)

Human peripheral blood cells or paraffin sections of spleen.

Cellular localization 

Cell membrane; Multi-pass membrane protein

Research areas 

Cardiovascular >> Atherosclerosis >> Vascular Inflammation >> Leukocyte recruitment >> Chemokines
Cancer >> Signal transduction >> G protein signaling >> GPCR
Signal Transduction >> Signaling Pathway >> G Protein Signaling >> GPCR
Microbiology >> Interspecies Interaction >> Host Virus Interaction
Immunology >> Innate Immunity >> Chemokines >> Beta Chemokine Rec. (CCR)
Immunology >> Innate Immunity >> Macrophage / Inflamm.
Neuroscience >> Neurology process >> Neurodegenerative disease >> Alzheimer's disease >> Other

Relevance 

The CC chemokine receptor 5 (CCR5) is a member of the CC-chemokine receptor family, and has the characteristic structure of a 7 transmembrane G protein-coupled receptor (GPCR). CCR5 regulates trafficking and effector functions of memory/effector Th1 cells, macrophages, NK cells, and immature dendritic cells. CCR5 and its ligands play an important role in viral pathogenesis. CCR5 represents the co-receptor for macrophage (M) and dual (T cell and M)-tropic immunodeficiency viruses. Together with the CD4 binding receptor, CCR5 plays a critical role in HIV entry into the target cells. Moreover, the CCR5 ligands macrophage inflammatory protein (MIP)-1 alpha, MIP-1 beta and RANTES act as endogenous inhibitors of HIV infection, making both CCR5 and its chemokine ligands attractive therapeutic targets for HIV infection. Recent studies have also highlighted the role of CCR5 in a variety of other human diseases, ranging from infectious and inflammatory diseases to cancer.

Database links 

Raised in 

Goat

Clonality 

Polyclonal

Isotype 

IgG

Purity 

Immunogen affinity purified

Storage buffer 

PBS, 1mg/ml BSA, 0.1% sodium azide, pH7.2

Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS

Form 

Liquid

Concentration 

1.000 mg/ml

Storage instructions 

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

See below for CCR5 antibody images, references, products related to ab1673 and other tools.

CCR5 antibody images:

References for CCR5 antibody (ab1673)

  This product has been used in: (two most recent references)

Tan MC et al. Disruption of CCR5-dependent homing of regulatory T cells inhibits tumor growth in a murine model of pancreatic cancer. J Immunol 182:1746-55 (2009). IHC-P; Human. PubMed: 19155524

Moutsopoulos NM et al. Tonsil epithelial factors may influence oropharyngeal human immunodeficiency virus transmission. Am J Pathol 171:571-9 (2007). PubMed: 17620369

See all 5 publication references for this product.


If you publish research using ab1673 please let us know so that we can cite the reference on this datasheet.

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