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Product Name
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CCR6 antibody [53103.111]
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See all CCR6 antibodies (5)...
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Product type
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Primary antibodies
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Description
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Mouse monoclonal [53103.111] to CCR6
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Immunogen
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Human CCR6 transfected NSO mouse myeloma cells.
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Reacts with
(species key)
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Hu
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Specificity
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Human CCR6 reacts with CCR6 transfected cells and not with the parent cell line by flow cytometry.
The antibody shows no cross-reactivity with CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CXCR1, CXCR2, CXCR3, CXCR4 and STRL33 transfected cells.
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Tested applications
(see key)
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Flow Cyt
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Abreviews
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Application notes
(see key)
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Recommended dilutions
Flow Cyt: Use 5µg for 105 cells. (Determined using human CCR-6 on peripheral blood mononuclear cells (PBMC)).
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Cell membrane; Multipass membrane protein.
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Research areas
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Signal Transduction >> Signaling Pathway >> G Protein Signaling >> GPCR
Immunology >> Innate Immunity >> Chemokines >> Beta Chemokine Rec. (CCR)
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Relevance
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CCR6 is a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein coupled receptors. It is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP 3 alpha). This receptor has been shown to be important for B lineage maturation and antigen driven B cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses.
CCR6 has been reported to be expressed in intestine, colon, liver, lymph node, spleen, lung, blood, umbilical cord, placenta, skin, and pancreas. It has also been reported to be expressed in lymphocytes, T cells, and B cells.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Mouse
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Clonality
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Monoclonal
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Clone number
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53103.111
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Myeloma
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NS0
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Isotype
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IgG2b
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Purity
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Protein G purified
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Storage buffer
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Preservative: None
Constituents: PBS
Endotoxin level is < 10 ng per mg antibody as determined by the LAL method.
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Purification notes
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The antibody is purified from ascites fluid using protein G chromatography.
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Form
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Liquid
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Concentration
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0.500 mg/ml
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Storage instructions
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Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this CCR6 antibody [53103.111] is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to CCR6
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