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Products:Immunology >> Innate Immunity >> Chemokines >> Beta Chemokine Rec. (CCR)
Overview
Product name
Anti-CCR6 antibody
See all CCR6 products (5) ...
Description
Goat polyclonal to CCR6
Tested applications
IHC-Fr, ELISA, ICC, IHC-Pmore details
Cross reactivity
Reacts with
Human
Does not react with
Mouse
Immunogen
Synthetic peptide: YFVSVNTSYYSVDSEMLLCSLQEVRQFSR, corresponding to amino acids 18-46 of Human CCR6.
YFVSVNTSYY SVDSEMLLCS LQEVRQFSR
Positive control
Human spleen or peripheral blood
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
PBS, 1mg/ml BSA, 0.1% sodium azide, pH7.2
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Signal Transduction >> Signaling Pathway >> G Protein Signaling >> GPCR
Immunology >> Innate Immunity >> Chemokines >> Beta Chemokine Rec. (CCR)
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - CCR6 antibody (ab1659)
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Applications
Show applications key
Our Abpromise guarantee covers the use of ab1659 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IHC-Fr
ELISA
ICC
- 1 Image
IHC-P
Application notes
ELISA: 1/75000.
ICC: 1/300.
IHC-P: 1/250.
IHC-Fr: 1/250 (PMID 19095953).
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Function
Receptor for a C-C type chemokine. Binds to MIP-3-alpha/LARC and subsequently transduces a signal by increasing the intracellular calcium ions level.
Tissue specificity
Spleen, lymph nodes, appendix, and fetal liver. Expressed in lymphocytes, T-cells and B-cells but not in natural killer cells, monocytes or granulocytes.
Sequence similarities
Belongs to the G-protein coupled receptor 1 family.
Cellular localization
Cell membrane.
Target information above from: UniProt accessionP51684
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- BN 1 antibody
- BN1 antibody
- C C chemokine receptor type 6 antibody
see all
Database links
- Entrez Gene: 1235 Human
- Omim: 601835 Human
- SwissProt: P51684 Human
- Unigene: 46468 Human
Anti-CCR6 antibody images:
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - CCR6 antibody (ab1659)
Immunohistochemistry on paraffin section of human spleen, at 1/250 dilution.
References for Anti-CCR6 antibody (ab1659)
This product has been referenced in:
- Salim SYet al. CD83+CCR7- dendritic cells accumulate in the subepithelial dome and internalize translocated Escherichia coli HB101 in the Peyer's patches of ileal Crohn's disease. Am J Pathol 174:82-90 (2009). IHC-Fr; Human.Read more (PubMed: 19095953) »
See 1 publication for this product
Publishing research using ab1659? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"