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Products:Immunology >> Adaptive Immunity >> B Cells >> CD
Overview
Product name
Anti-CD10 antibody [FR4D11/F3]
See all CD10 products (33) ...
Description
Mouse monoclonal [FR4D11/F3] to CD10
Tested applications
Flow Cytmore details
Cross reactivity
Reacts with
Human
Properties
Form
Liquid
Storage instructions
Store at +4°C.
Storage buffer
PBS with 0.5% BSA and 0.1% sodium azide
Concentration
Concentration information loading...
Purity
IgG fraction
Clonality
Monoclonal
Clone number
FR4D11/F3
Myeloma
unknown
Isotype
IgG1
Light chain type
unknown
Research areas
Cancer >> Tumor immunology >> CD markers
Stem Cells >> Mesenchymal Stem Cells >> Surface Molecules
Stem Cells >> Hematopoietic Progenitors >> Hematopoietic Stem Cells >> Human Lineage Negative
Immunology >> Cell Type Markers >> CD >> Non-lineage
Immunology >> Adaptive Immunity >> B Cells >> CD
Applications
Show applications key
Our Abpromise guarantee covers the use of ab1251 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Flow Cyt
Application notes
Characterization of leukaemias and lymphomas in human lysed whole peripheral blood or mononuclear cells separated by density gradient.
Childhood ALL prognosis (patients CD10+ have a better prognosis than CD10-).
CD10 immunofluorescence analysis can be performed on a flow cytometerequipped with an excitation source of 488nm and fitted with logarithmic amplifiers.
10µl ofCD10 is sufficient for labelling of 1x106 cells.
Target
Function
Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers.
Sequence similarities
Belongs to the peptidase M13 family.
Cellular localization
Cell membrane.
Target information above from: UniProt accessionP08473
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- Atriopeptidase antibody
- CALLA antibody
- CD 10 antibody
see all
Database links
- Entrez Gene: 4311 Human
- Omim: 120520 Human
- SwissProt: P08473 Human
- Unigene: 307734 Human
References for Anti-CD10 antibody [FR4D11/F3] (ab1251)
ab1251 has not yet been referenced specifically in any publications.
Publishing research using ab1251? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"