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- Secondary antibodies
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Product name
Anti-CD105 antibody
See all CD105 products (32) ...
Description
Rabbit polyclonal to CD105
Tested applications
ELISA, WBmore details
Cross reactivity
Reacts with
Mouse
Immunogen
Highly pure recombinant mouse soluble CD105 (aas 26-581) bearing His 6 C-terminal tag.
Properties
Form
Lyophilised:
The lyophilized IgG is stable at 4°C for at least six months and for greater than a year when kept at –20°C. When reconstituted in sterile water/PBS to a concentration of >0.5 mg/ml the antibody is stable for at least six weeks at 2-4°C. Avoid repeated freeze-thaw cycles.
Storage instructions
Store at +4°C. Aliquot and store at -20°C or -80°C when reconstituted. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
Constituents: PBS, pH 7.4
Concentration
Concentration information loading...
Purity
Protein A purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Cardiovascular >> Cardiovascular Markers >> Cell Markers >> Endothelial Cells
Stem Cells >> Endothelial Progenitors >> Endothelial Markers
Cardiovascular >> Vasculature >> Endothelium
Cancer >> Tumor biomarkers >> Other
Stem Cells >> Mesenchymal Stem Cells >> Surface Molecules
Immunology >> Cell Type Markers >> CD >> Endothelial Cells
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Western blot - CD105 antibody (ab21222)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab21222 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ELISA: Use a concentration of 1 - 15 µg/ml.
WB: Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 71 kDa.
Target
Function
Major glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors.
Tissue specificity
Endoglin is restricted to endothelial cells in all tissues except bone marrow.
Involvement in disease
Defects in ENG are the cause of hereditary hemorrhagic telangiectasia type 1 (HHT1) [MIM:187300, 108010]; also known as Osler-Rendu-Weber syndrome 1 (ORW1). HHT1 is an autosomal dominant multisystemic vascular dysplasia, characterized by recurrent epistaxis, muco-cutaneous telangiectases, gastro-intestinal hemorrhage, and pulmonary (PAVM), cerebral (CAVM) and hepatic arteriovenous malformations; all secondary manifestations of the underlying vascular dysplasia. Although the first symptom of HHT1 in children is generally nose bleed, there is an important clinical heterogeneity.
Cellular localization
Membrane.
Target information above from: UniProt accessionP17813
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- CD 105 antibody
- CD105 antibody
- CD105 antigen antibody
see all
Database links
- Entrez Gene: 13805 Mouse
- SwissProt: Q63961 Mouse
- Unigene: 225297 Mouse
Anti-CD105 antibody images:
Western blot - CD105 antibody (ab21222)
All lanes : Anti-CD105 antibody (ab21222)
Lane 1 : Recombinant mouse soluble CD105
Lane 2 : Recombinant human soluble CD105
Predicted band size : 71 kDa
Observed band size : 71 kDa
References for Anti-CD105 antibody (ab21222)
ab21222 has not yet been referenced specifically in any publications.
Publishing research using ab21222? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"